PMID: 6110464Feb 9, 1981Paper

Difference in choline acetyltransferase but similarities in catecholamine biosynthetic enzymes in brains of two rat strains differing in their response to stress

Brain Research
G M Gilad, R McCarty

Abstract

Rats of the Wistar-Kyoto (WKY) strain are more reactive to stress than Brown-Norway (BN) rats as adjudged by their behavioral and plasma catecholamine (CA) responses to stress. Contrary to the strain differences existing in the periphery, brain CA and their biosynthetic enzyme activities were found to be similar in both strains before and after immobilization stress. However, as in the periphery, choline acetyltransferase (CAT) activity was higher in brains of WKY rats. The results suggest that: (1) peripheral and central CA systems may be under different genetic control mechanisms, and (2) strain differences in CAT activity may reflect differences in cholinergic systems both in the brain and periphery, which may be important in the behavioral differences observed.

References

Nov 2, 1979·Brain Research·G M GiladI J Kopin
Aug 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·A H TissariG L Gessa
Oct 27, 1978·Brain Research·R KvetñanskýJ M Saavedra
Feb 1, 1963·Biochemical Pharmacology·E ROBERTS, D G SIMONSEN

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Citations

Jul 8, 1985·Brain Research·B D BossW M Cowan
May 1, 1992·Physiology & Behavior·F J van der StaayS Kerbusch
Mar 1, 1995·Mechanisms of Ageing and Development·G M Gilad, V H Gilad
Feb 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S A Ferguson, R R Holson
Sep 23, 1985·Brain Research·Y FinkelsteinG M Gilad
Oct 20, 1987·Brain Research·M FatranskáR Kvetnanský
Dec 17, 2009·Behavioral and Brain Functions : BBF·F Josef van der StaayS Mechiel Korte
Dec 1, 1981·Developmental Psychobiology·R McCartyK Baucom
Jan 1, 1984·Behavioral and Neural Biology·R McCartyP G Garn

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