Difference in clinical presentation between women and men in incident primary Sjögren's syndrome

Biology of Sex Differences
Jorge I Ramírez SepúlvedaM Wahren-Herlenius

Abstract

A more severe disease phenotype has been reported in men compared to women in several rheumatic diseases. However, studies have not conclusively established sex-related clinical features in primary Sjögren's syndrome (pSS). In this study, we therefore investigated the clinical presentation of pSS in women and men at diagnosis. Incident, treatment naïve patients (n = 199) during a 5-year period in a specified area were prospectively included and examined for items of classification criteria for pSS as well as extraglandular manifestations (EGM). Serum was sampled at the time of diagnosis and anti-Ro52/SSA levels were measured by ELISA. Replication of significant findings was confirmed in an independent cohort of pSS patients (n = 377), and meta-analysis was performed. An increased frequency of extraglandular manifestations in men was observed and replicated (p = 0.05, p = 0.0003, and pmeta = 0.002). This related to pulmonary involvement, vasculitis, and lymphadenopathy being more common in men, for whom a lower age at diagnosis was observed in the exploratory cohort. Additionally, SSA-positive male patients had significantly higher levels of anti-Ro52 levels than their female counterparts in sera available for analysis (p = 0.02...Continue Reading

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Citations

Feb 21, 2018·Acta Neuropathologica Communications·Najla KfouryJoshua B Rubin
Apr 30, 2019·Expert Review of Clinical Immunology·Carlo Selmi, M Eric Gershwin
Aug 10, 2017·Biology of Sex Differences·Jorge I Ramírez SepúlvedaMarie Wahren-Herlenius
Sep 13, 2020·International Journal of Rheumatic Diseases·Youngjae ParkSeung-Ki Kwok
Dec 18, 2019·Biology of Sex Differences·Jorge I Ramírez SepúlvedaMarie Wahren-Herlenius
Oct 4, 2020·Nature Reviews. Rheumatology·Maurizio Cutolo, Rainer H Straub
Aug 3, 2021·Frontiers in Immunology·Juliana Imgenberg-KreuzGunnel Nordmark

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