Abstract
This study was designed to utilize frequency-domain optical coherence tomography (FD-OCT) for assessment of plaque characteristics and vulnerability in patients with acute coronary syndrome (ACS) compared to stable coronary artery disease (SCAD). We enrolled 48 patients; divided into an ACS-group (27 patients) and SCAD-group (21 patients) according to their clinical presentation. Hypertension and diabetes mellitus were more prevalent in SCAD group. Patients with ACS showed higher frequency of lipid-rich plaques (96.3% vs. 66.7%, P = .015), lower frequency of calcium plaques (7.4% vs. 57.1%, P < .001), and fibrous plaques (14.8% vs. 81%, P < .001) when compared with SCAD patients. The TCFA (defined as lipid-rich plaque with cap thickness <65 μm) identified more frequently (33.3% vs. 14.3%, P = .185), with a trend towards thinner median fibrous cap thickness (70 (50-180) µm vs. 100 (50-220) µm, P = .064) in ACS group. Rupture plaque (52% vs. 14.3%, P = .014), plaque erosion (18.5% vs. 0%, P = .059) and intracoronary thrombus (92.6% vs. 14.3%, P < .001) were observed more frequently in ACS group, while cholesterol crystals were identified frequently in patients with SCAD (0.0% vs. 33.3%, P = .002). The current FD-OCT study demonst...Continue Reading
References
Jan 30, 1992·The New England Journal of Medicine·K MizunoJ A Ambrose
Nov 1, 1988·Circulation·W C LittleW P Santamore
Apr 1, 1996·Circulation·A FarbR Virmani
Jun 17, 1998·Circulation·A P BurkeR Virmani
Oct 5, 2001·Current Opinion in Cardiology·F D KolodgieR Virmani
Jan 8, 2003·Circulation·Guillermo J TearneyBrett E Bouma
Jun 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Briain D MacNeillIk-Kyung Jang
Oct 8, 2003·Circulation·Morteza NaghaviJames T Willerson
Aug 18, 2004·Circulation·Myeong-Ki HongSeung-Jung Park
Mar 23, 2005·Circulation·Ik-Kyung JangBrett E Bouma
Mar 30, 2006·American Heart Journal·Jerzy PregowskiNeil J Weissman
Apr 18, 2006·The American Journal of Cardiology·Teruyoshi KumeKiyoshi Yoshida
Apr 25, 2006·Journal of the American College of Cardiology·Renu VirmaniFrank D Kolodgie
Apr 29, 2006·American Heart Journal·Gastón A Rodriguez-GranilloPatrick W Serruys
Sep 4, 2007·Journal of the American College of Cardiology·Takashi KuboTakashi Akasaka
Sep 4, 2007·Journal of the American College of Cardiology·Pavan K CheruvuJames E Muller
Aug 23, 2008·Journal of the American College of Cardiology·Kenichi FujiiMitsumasa Ohyanagi
Jul 21, 2009·The American Journal of Cardiology·Matthijs F L MeijsMaarten J Cramer
Nov 7, 2009·European Heart Journal·Francesco PratiUNKNOWN Expert's OCT Review Document
Jan 28, 2010·The American Journal of Cardiology·Takashi KuboTakashi Akasaka
Feb 18, 2010·JACC. Cardiovascular Imaging·Kenichi FujiiTohru Masuyama
Jun 12, 2010·The American Journal of Cardiology·Hironori KitabataTakashi Akasaka
Sep 24, 2011·Cardiology Research and Practice·Takashi KuboTakashi Akasaka
Jun 2, 2012·European Heart Journal·Francesco PratiUNKNOWN Expert's OCT Review Document
Mar 23, 2013·JACC. Cardiovascular Interventions·Hiram G BezerraMarco A Costa
Apr 2, 2013·The American Journal of Cardiology·Masato MizukoshiTakashi Akasaka
Oct 25, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Sebastian ReithMathias Burgmaier
Dec 21, 2013·Coronary Artery Disease·Luca Di VitoUNKNOWN COICO group (Consortium of Investigators for Coronary OCT)
Jun 29, 2015·JACC. Cardiovascular Interventions·Takumi HigumaIk-Kyung Jang
Jan 23, 2016·Expert Review of Cardiovascular Therapy·Yoshiki MatsuoTakashi Akasaka
Sep 10, 2016·Circulation. Cardiovascular Interventions·Takumi HigumaIk-Kyung Jang