Difference in plasma metabolite concentration after ingestion of lemon flavonoids and their aglycones in humans

Journal of Nutritional Science and Vitaminology
Yoshiaki MiyakeKazuo Kondo

Abstract

The concentrations of metabolites in human plasma after ingestion of flavanone glycosides (FG) and their aglycones (FA) in lemon were examined. FG consisting abundantly of eriocitrin were prepared from lemon peel and FA consisting abundantly of eriodictyol were prepared from FG by treatment with beta-glucosidase. Eriodictyol, homoeriodictyol, and hesperetin in plasma up to 4 h after ingestion of FG with water or FA with water by subjects were not detected in plasma of non-enzyme treatment but in plasma after treatment with beta-glucronidase and sulfatase. Metabolites in plasma after ingestion of FG and FA in humans were shown to exist as the glucuro- and/or sulfo-conjugates of eriodictyol, homoeriodictyol, and hesperetin. After ingestion of FA, the concentration of metabolites in plasma exhibited a high maximum peak at 1 h. The AUC (area under the blood concentration time curve) level of metabolites of FA was higher than that of FG. FA were suggested to be absorbed faster and in higher amounts than FG. The AUC of metabolites in subject plasma after ingestion of FG with flavonoid-depleted lemon juice was shown to change to a low level in comparison with that of FG with water. The maximum concentration peak of metabolites in plas...Continue Reading

References

Jan 1, 1992·Toxicology and Applied Pharmacology·T J MonksD G Graham
Jul 1, 1996·Clinical Pharmacology and Therapeutics·B AmeerR L Rouseff
Oct 12, 1999·JAMA : the Journal of the American Medical Association·K J JoshipuraW C Willett
Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P C Hollman, M B Katan
Dec 20, 1999·Journal of Agricultural and Food Chemistry·S KawaiiM Yano
Jan 5, 2000·The American Journal of Clinical Nutrition·J R BellS E Kasim-Karakas
Jan 20, 2000·Journal of the National Cancer Institute·L Le MarchandL N Kolonel
Jun 11, 2002·Annual Review of Nutrition·Julie A Ross, Christine M Kasum
Dec 12, 2002·Journal of Agricultural and Food Chemistry·G MazzaBruce J Holub
Jan 29, 2003·Life Sciences·Ken-ichiro MinatoToshihiko Osawa
Apr 17, 2003·Journal of Agricultural and Food Chemistry·Inge Lise F NielsenSalka E Rasmussen
Aug 19, 2003·Archives of Biochemistry and Biophysics·Kaeko Murota, Junji Terao
Oct 7, 2004·Phytochemistry·Elio G W M SchijlenArnaud G Bovy

❮ Previous
Next ❯

Citations

May 11, 2007·Archives of Pharmacal Research·Young-Suk KimDong-Hyun Kim
Mar 2, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Helmut M HügelCharlie C Xue
Nov 3, 2007·Phytochemistry·Juan Carlos EspínFrancisco A Tomás-Barberán
Feb 4, 2021·Journal of Agricultural and Food Chemistry·Paula S FerreiraThais B Cesar
Aug 6, 2009·Journal of Agricultural and Food Chemistry·Ahcene BoumendjelDenis Barron
Aug 3, 2021·EFSA Journal·UNKNOWN EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Birgit Dusemund
Jan 10, 2012·Journal of Agricultural and Food Chemistry·Sam-Long HwangGow-Chin Yen
Aug 28, 2007·Journal of Pharmaceutical and Biomedical Analysis·Karina R Vega-VillaNeal M Davies

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.