Difference in post-stress recovery of the gut microbiome and its altered metabolism after chronic adolescent stress in rats.

Scientific Reports
Mengyang XuJiangjiang Zhu

Abstract

The human gut microbiome plays a central role in human health, and has been implicated in the development of a number of chronic gastrointestinal and systemic diseases. For example, microorganisms can serve as microbial endocrine mediators and can respond to stimuli and produce neurochemicals, ultimately influencing the brain-gut-microbiome axis of their host, a bidirectional communication system between the central nervous system and the gastrointestinal tract, especially during developmental stages. To begin to explore potential dynamic changes of the gut microbiome, we characterized gut microbiota in adolescent rats that underwent a fixed period of restraint stress, examined whether the gut microbial population and their metabolic functions were changed by stress, and if such changes during adolescence persist or recover in young adulthood. Integrated 16S ribosomal DNA sequencing and liquid chromatography coupled tandem mass spectrometry (LC-MS/MS) based metabolic profiling were utilized to discover any significant differences in gut microbial genus and microbial metabolites immediately at the end of the chronic restraint stress and three weeks after the stress treatment, compared to control rats that did not receive stress ...Continue Reading

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Citations

Oct 23, 2020·Indian Journal of Microbiology·Helianthous VermaCharu Dogra Rawat
Jun 19, 2021·The Journal of Trauma and Acute Care Surgery·Lauren S KellyAlicia M Mohr

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Methods Mentioned

BETA
amplicon sequencing
ELISA
PCR
electrophoresis
Assay

Software Mentioned

JMP Pro12
Quan Browser
MetaboAnalyst
vegan
Xcalibur
R
QIIME
Prism
PERMANOVA

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