PMID: 11907351Mar 22, 2002Paper

Difference in prognostic value between sialyl Lewis(a) and sialyl Lewis(x) antigen levels in the preoperative serum of gastric cancer patients

Journal of Clinical Gastroenterology
Tohru NakagoeHiroshi Ishikawa

Abstract

Sialyl Lewis(a) (CA19-9) and sialyl Lewis(x) antigens (SLX) may play a role in tumor metastasis by serving as functional ligands in the cell adhesion system. The authors examined preoperative serum levels of CA19-9 and SLX in 218 patients who underwent resection for gastric cancer to determine their prognostic value. The patients were divided into two groups, termed the low and high antigen groups, based on a value selected as a diagnostic cutoff. Correlation between the antigen serum levels, various established clinicopathologic factors, and prognosis were studied by univariate and multivariate analysis. The disease-specific interval for high CA19-9 and SLX groups was significantly shorter than that of their respective low groups (p = 0.0024 and p < 0.0001, respectively). Patients with stage III/IV tumors who had high serum SLX levels had shorter disease-specific intervals than those with low serum levels (p = 0.0017). A Cox's regression analysis revealed a high serum SLX level as an independent factor for worse outcome. In addition, logistic regression analysis revealed that a high serum SLX level was an independent predictor for liver metastasis. In conclusion, an elevated preoperative serum SLX level was a predictor for poo...Continue Reading

References

Jan 1, 1977·British Journal of Haematology·J Palek
Jun 1, 1989·Gastroenterologia Japonica·T DohiS Ohshiba
Jul 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C Infante-RivardJ P Villeneuve
Jan 1, 1994·Advances in Experimental Medicine and Biology·T Irimura
Aug 1, 1996·The Journal of Pathology·E Dabelsteen
Nov 21, 1996·Biochemical and Biophysical Research Communications·M NguyenS Defrees
Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S NakamoriT Irimura
Nov 18, 1998·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·S E BaldusH P Dienes
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Y MaeharaK Sugimachi
May 2, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Mitsugu KochiMotoo Yamagata

❮ Previous
Next ❯

Citations

Mar 27, 2010·Surgery Today·Yoshihiro KakejiYoshihiko Maehara
Nov 16, 2012·Journal of Biosciences·Noé Velázquez-MárquezVerónica Vallejo-Ruiz
Mar 25, 2009·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Fania S DoekhiePeter J K Kuppen
Aug 3, 2005·Nature Reviews. Cancer·Mark M Fuster, Jeffrey D Esko
Apr 28, 2011·The Journal of Biological Chemistry·Kazuhiro ShiozakiTaeko Miyagi
Jul 16, 2008·Biochemical and Biophysical Research Communications·Kazuhiro TanabeKazuhiro Ikenaka
Apr 6, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael J CzerwinskiSilvana Papagerakis
May 27, 2004·World Journal of Gastroenterology : WJG·Lei ShenJun Sun
Aug 10, 2004·International Journal of Cancer. Journal International Du Cancer·Johanna LouhimoCaj Haglund
Apr 15, 2016·Clinical & Experimental Metastasis·Nina SluiterElisabeth Atie Te Velde
May 26, 2004·Archives of Biochemistry and Biophysics·John L Magnani
Dec 18, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chong-Jen YuPan-Chyr Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
E M H A de Kleijn, C J A Punt
© 2022 Meta ULC. All rights reserved