Difference in regional neural fluctuations and functional connectivity in Crohn's disease: a resting-state functional MRI study.

Brain Imaging and Behavior
Chunhui BaoHuangan Wu

Abstract

Patients with Crohn's disease (CD) are shown to have abnormal changes in brain structures. This study aimed to further investigate whether these patients have abnormal brain activities and network connectivity. Sixty patients with CD and 40 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (fMRI) scans. Amplitude of low-frequency fluctuation (ALFF) and seed-based functional connectivity (FC) were used to assess differences in spontaneous regional brain activity and functional connectivity. Compared to the HCs, patients with CD showed significantly higher ALFF values in hippocampus and parahippocampus (HIPP/paraHIPP), anterior cingulate cortex, insula, superior frontal cortex and precuneus. The ALFF values were significantly lower in secondary somatosensory cortex (S2), precentral gyrus, and medial prefrontal cortex. Functional connectivities between left HIPP and left inferior temporal cortex, and right middle cingulate cortex, HIPP, and fusiform area were significantly lower. The functional connectivities between right HIPP and right inferior orbitofrontal cortex and left HIPP were also significantly lower. Patients with CD showed higher or lower spontaneous activity in multiple brain regions...Continue Reading

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Citations

Mar 7, 2020·Frontiers in Neurology·Jennifer KornelsenCharles N Bernstein
Dec 29, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Anne Kerstin ThomannRobert Christian Wolf
Apr 9, 2021·JAMA Otolaryngology-- Head & Neck Surgery·Aria JafariBenjamin S Bleier

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Methods Mentioned

BETA
biopsy

Software Mentioned

Statistical Product and Service Solutions ( SPSS )
ALFF
REST

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