Difference in signal transduction for IL-10 and IFN-gamma production in a CD8+ T cell clone

Cellular Immunology
Y MinaiS Kaminogawa

Abstract

CD8+ T cell clones produced both interleukin 10 (IL-10) and interferon-gamma (IFN-gamma) when these cells were stimulated with a T-cell-specific mitogen, concanavalin A (Con A). One of these CD8+ T cell clones, 13G2, secreted IFN-gamma at similar levels with calcium ionophore, A23187, as well as by Con A, but IL-10 production by A23187 was less than by Con A. On the other hand, N6,O2-dibutyryl cAMP enhanced the production of IL-10 but not IFN-gamma when the low doses of Con A or A23187 coexisted. In a T cell clone, the production of these two cytokines required different signal transductions. These results indicate that a T cell clone can produce diverse cytokines depending on the surrounding condition.

Citations

Sep 1, 1999·Immunology·A W RowbottomE G Corley
May 23, 2001·International Immunopharmacology·N OsnaM M Khan
Nov 26, 2019·European Journal of Immunology·Hideki Ueno
Jan 11, 2020·Immunology and Cell Biology·Jing-Yi LinLi-Fang Wang
May 9, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zhenyuan SongCraig McClain

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