Difference in substrate specificity divides the yeast alkali-metal-cation/H(+) antiporters into two subfamilies

Microbiology
Olga KinclováHana Sychrova

Abstract

Yeast plasma membrane Na(+)/H(+) antiporters (TC 2.A.36) share a high degree of similarity at the protein level. Expression of four antiporters (Saccharomyces cerevisiae Nha1p, Candida albicans Cnh1p, Zygosaccharomyces rouxii ZrSod2-22p and Schizosaccharomyces pombe sod2p) in a SACCH: cerevisiae mutant strain lacking both Na(+)-ATPase and Na(+)/H(+) antiporter genes made it possible to study the transport properties and contribution to cell salt tolerance of all antiporters under the same conditions. The ZrSod2-22p of the osmotolerant yeast Z. rouxii has the highest transport capacity for lithium and sodium but, like the SCHIZ: pombe sod2p, it does not recognize K(+) and Rb(+) as substrates. The SACCH: cerevisiae Nha1p and C. albicans Cnh1p have a broad substrate specificity for at least four alkali metal cations (Na(+), Li(+), K(+), Rb(+)), but their contribution to overall cell tolerance to high external concentration of toxic Na(+) and Li(+) cations seems to be lower compared to the antiporters of SCHIZ: pombe and especially Z. rouxii.

References

Oct 21, 1991·FEBS Letters·R HaroA Rodríguez-Navarro
Aug 1, 1991·Molecular and Cellular Biology·C H Ko, R F Gaber
Sep 1, 1984·Journal of Bacteriology·A Rodríguez-Navarro, J Ramos
Aug 30, 1994·Biochimica Et Biophysica Acta·A Rodríguez-NavarroB Garciadeblás
Jan 1, 1994·Journal of Bacteriology·J RamosA Rodriguez-Navarro
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·K M HahnenbergerP G Young
Jan 27, 1998·The Journal of Biological Chemistry·M A Bañuelos, A Rodríguez-Navarro
Mar 20, 1999·Biochimica Et Biophysica Acta·M H SaierG B Young
Feb 29, 2000·Biochimica Et Biophysica Acta·A Rodríguez-Navarro
May 22, 2001·Molecular Microbiology·O KinclováH Sychrová
Aug 28, 2001·FEBS Letters·O KinclováH Sychrová
Nov 1, 1995·Plant Physiology·X. NiuJ. M. Pardo
Oct 20, 2005·Journal of Bioscience and Bioengineering·Y WatanabeY Tamai

❮ Previous
Next ❯

Citations

Feb 24, 2015·Journal of Molecular Biology·Olga Kinclova-ZimmermannovaHana Sychrova
Mar 1, 2006·Biochimica Et Biophysica Acta·Hana FlegelovaHana Sychrova
Jul 24, 2010·Biochimica Et Biophysica Acta·Alonso Rodríguez-Navarro, Begoña Benito
Mar 11, 2010·FEMS Yeast Research·Obakeng M TekoloBernard A Prior
Jan 19, 2011·FEMS Microbiology Letters·José RamosHana Sychrová
Jul 19, 2002·Yeast
Aug 4, 2006·The Journal of Antibiotics·Hiroshi WatanabeHiroshi Ooshima
Dec 9, 2017·IUBMB Life·Debajyoti Dutta, Larry Fliegel
Jul 31, 2007·Microbiology·Olga Kinclova-Zimmermannova, Hana Sychrová
Oct 14, 2003·FEMS Yeast Research·Fernando Calero, José Ramos
Mar 4, 2010·Microbiology and Molecular Biology Reviews : MMBR·Joaquín AriñoHana Sychrová
Mar 11, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Zhala MeranRichard D Handy
Aug 6, 2021·Frontiers in Microbiology·Sandra MoroM-Henar Valdivieso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.