Difference in the breast milk proteome between allergic and non-allergic mothers

PloS One
Kasper HettingaAlet H Wijga

Abstract

Breastfeeding has been linked to a reduction in the prevalence of allergy and asthma. However, studies on this relationship vary in outcome, which may partly be related to differences in breast milk composition. In particular breast milk composition may differ between allergic and non-allergic mothers. Important components that may be involved are breast milk proteins, as these are known to regulate immune development in the newborn. The objective of this study was therefore to explore differences in the proteins of breast milk from 20 allergic and non-allergic mothers. The results from this comparison may then be used to generate hypotheses on proteins associated with allergy in their offspring. Milk samples from allergic and non-allergic mothers were obtained from the PIAMA project, a prospective birth cohort study on incidence, risk factors, and prevention of asthma and inhalant allergy. Non-targeted proteomics technology, based on liquid chromatography and mass spectrometry, was used to compare breast milk from allergic and non-allergic mothers. Nineteen proteins, out of a total of 364 proteins identified in both groups, differed significantly in concentration between the breast milk of allergic and non-allergic mothers. Pr...Continue Reading

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Citations

Nov 26, 2015·Proteomics·Cristian PirasAlessio Soggiu
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Mar 27, 2021·Journal of Proteome Research·Loïc DayonMichael Affolter

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Methods Mentioned

BETA
Protein Assay
acetylation

Software Mentioned

Perseus
MaxQuant
DAVID GO
DAVID

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