Difference in the induction of macrophage interleukin-1 production between viable and killed cells of Listeria monocytogenes.

Infection and Immunity
M MitsuyamaK Nomoto

Abstract

T-cell-mediated immunity to Listeria monocytogenes in mice, as determined by delayed-type hypersensitivity and acquired resistance, was induced by immunization with viable bacteria but not with killed bacteria, even when killed cells were injected in a high dose or repeatedly. T cells obtained from mice immunized with viable L. monocytogenes were readily stimulated with killed-bacterial antigens, resulting in T-cell proliferation in vitro and expression of a delayed footpad reaction in vivo. After immunization with killed-bacterial vaccine, T-cell responsiveness to interleukin 2 (IL-2) never developed but a lower level of responsiveness to IL-1 appeared later than with T cells from mice immunized with viable bacteria. When IL-1 production by macrophages was examined in vitro, viable L. monocytogenes stimulated a high level of IL-1 release while killed bacteria did not. Avirulent strains which were ineffective in the induction of T-cell mediated immunity were incapable of inducing IL-1 production as well. The impaired ability of killed bacteria to stimulate IL-1 production was confirmed by the level of IL-1 mRNA expression. These results suggested that the ineffectiveness of killed L. monocytogenes vaccine is not due to loss or ...Continue Reading

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Jul 4, 2001·Clinical Microbiology Reviews·J A Vázquez-BolandJ Kreft
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mischo KursarHans-Willi Mittrücker
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Sep 1, 1994·Infection and Immunity·Y YamamotoH Friedman

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