Difference in the risk factors for coronary, renal and other peripheral arteriosclerosis in heterozygous familial hypercholesterolemia

Circulation Journal : Official Journal of the Japanese Circulation Society
Kunimasa YagiHiroshi Mabuchi

Abstract

The aim of the present study was to clarify the risk factors of several types of arteriosclerosis lesions in Japanese individuals with heterozygous familial hypercholesterolemia (FH): renal arteriosclerosis (RAS), abdominal aortic sclerosis (AOS), iliac arteriosclerosis (IAS) and coronary artery disease (CAD). Coronary angiography (CAG) and abdominal aortic angiography (AAA) were performed in 117 consecutive heterozygous FH subjects (79 men, 38 women; age 22-76). RAS (stenotic lesion or aneurysm) was observed in 39 cases (33%), predominantly in the proximal portion (74%) and both sides equally (right/left = 27/23). Most cases of RAS (64%) presented with <25% stenosis. The differences in the contributing risk factors for the progression and development of RAS, AOS, IAS and CAD in FH were then analyzed. Multiple logistic regression analyses showed independent risk factors for formation of atherosclerosis in each artery were: age alone for RAS; age and plasma low-density lipoprotein cholesterol (LDL-C) for AOS; age, LDL-C and high-density lipoprotein cholesterol (HDL-C) for IAS; and HDL-C and diabetes mellitus for CAD. In Japanese subjects with heterozygous FH, there are distinct risk factors for the development and progression of...Continue Reading

References

Nov 1, 1978·Metabolism: Clinical and Experimental·H MabuchiH Takeshita
Jul 1, 1986·Atherosclerosis·H MabuchiR Takeda
Nov 15, 1985·Hospital Practice·J L Goldstein, M S Brown
May 1, 1972·Annals of Internal Medicine·H G SchrottA G Motulsky
Jul 1, 1984·The American Journal of Cardiology·D L SprecherH B Brewer
Jun 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·H G KraftG Utermann
Feb 17, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·H G KraftG Utermann
Mar 11, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·B W HochleitnerG Wick
Jun 18, 2002·Nature·Bart Staels
Dec 25, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Masunori MatsuzakiUNKNOWN J-LIT Study Group. Japan Lipid Intervention Trial

❮ Previous
Next ❯

Citations

Feb 16, 2012·Journal of Atherosclerosis and Thrombosis·Takako SugisawaMariko Harada-Shiba
Jul 20, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ahmet Midhat ElmaciAhmet Ozel
Mar 8, 2016·Journal of Atherosclerosis and Thrombosis·Sang-Hak Lee
Nov 29, 2005·Journal of the American College of Surgeons·Joseph D RaffettoJames O Menzoian
Jun 8, 2018·Journal of Atherosclerosis and Thrombosis·Mariko Harada-ShibaUNKNOWN Working Group by Japan Atherosclerosis Society for Making Guidance of Familial Hypercholesterolemia
Apr 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Masa-aki KawashiriHiroshi Mabuchi
May 24, 2006·Expert Review of Cardiovascular Therapy·Anouk van der GraafMaud N Vissers
Oct 26, 2012·Journal of Atherosclerosis and Thrombosis·Mariko Harada-ShibaShizuya Yamashita
Feb 26, 2020·Current Medical Research and Opinion·Panagiotis AnagnostisDimitri P Mikhailidis
Aug 8, 2018·The Journal of Clinical Endocrinology and Metabolism·Frida EmanuelssonMarianne Benn
Aug 31, 2018·Disease Markers·Yoshimi KishimotoYukihiko Momiyama
Nov 23, 2020·Clinical Chemistry·Frida Emanuelsson, Marianne Benn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.