Differences between Angus and Holstein cattle in the Lupinus leucophyllus induced inhibition of fetal activity

Toxicon : Official Journal of the International Society on Toxinology
Benedict T GreenT Zane Davis

Abstract

Calves with congenital defects born to cows that have grazed teratogenic Lupinus spp. during pregnancy can suffer from what is termed crooked calf syndrome. Crooked calf syndrome defects include cleft palate, spinal column defects and limb malformations formed by alkaloid-induced inhibition of fetal movement. In this study, we tested the hypothesis that there are differences in fetal activity of fetuses carried by Holstein verses Angus heifers orally dosed with 1.1 g/kg dried ground Lupinus leucophyllus. Fetal activity was monitored via transrectal ultrasonography and maternal serum was analyzed for specific lupine alkaloids. There were more (P < 0.05) movements in fetuses of Holstein heifers than those in Angus heifers at eight and 12 h after oral dosing. In addition to serum alkaloid toxicokinetic differences, the Holstein heifers had significantly lower serum concentrations of anagyrine at 2, 4, and 8 h after oral dosing than Angus heifers. Holstein heifers also had significantly greater serum concentrations of lupanine at 12, 18 and 24 h after dosing than the Angus heifers. These results suggest that there are breed differences in susceptibility to lupine-induced crooked calf syndrome. These differences may also be used to ...Continue Reading

References

Mar 1, 1993·The Veterinary Clinics of North America. Food Animal Practice·K E Panter, R F Keeler
May 23, 2009·Developmental Cell·Joy KahnElazar Zelzer
Feb 2, 2010·Neurotoxicology and Teratology·Benedict T GreenWilliam R Kem
Feb 24, 2010·Computer Methods and Programs in Biomedicine·Yong ZhangShaofei Xie
Jul 17, 2010·Journal of Applied Toxicology : JAT·Benedict T GreenT Zane Davis
Aug 2, 2012·American Journal of Veterinary Research·Benedict T GreenKip E Panter
May 15, 2013·Research in Veterinary Science·Benedict T GreenStephen T Lee
Jul 16, 2013·Chemical Research in Toxicology·Benedict T GreenStephen T Lee
Dec 18, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Kip E PanterBenedict T Green
Dec 18, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Benedict T GreenKip E Panter
Apr 29, 2015·Research in Veterinary Science·Benedict T GreenT Zane Davis

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Citations

Feb 17, 2018·Toxicon : Official Journal of the International Society on Toxinology·B T GreenW R Kem

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