Differences between ceftizoxime and its stereoisomer in antibacterial activity and affinity for penicillin-binding proteins.

Antimicrobial Agents and Chemotherapy
Y ShigiM Nishida

Abstract

A new cephalosporin derivative, ceftizoxime (syn FK 749), and its anti isomer, FR 14060, were compared in antibacterial activity, outer membrane permeability, stability to beta-lactamases, and affinity for penicillin-binding proteins (PBPs), using Escherichia coli NIHJ JC-2 and Enterobacter cloacae 58-5 as the test organisms. Although ceftizoxime was superior in antibacterial activity to FR 14060, no marked differences between the two agents were found in outer membrane permeability and stability to cephalosporinase. However, the affinity for PBPs and stability to penicillinase of ceftizoxime and FR 14060 differed significantly. Concentrations of ceftizoxime required to reduce [14C]penicillin G binding by 50% were below 1 microgram/ml for PBPs 1a and 1bs of E. cloacae 58-5 and below 3.2 microgram/ml for PBPs 1a and 1bs of E. coli NIHJ JC-2. A more than 10-fold-higher concentration of FR 14060 was required for 50% reduction of (14C]penicillin G binding to PBP 1bs of strains tested. Ceftizoxime was severalfold more stable than FR 14060 to penicillinase, but the antibacterial activity of both drugs against penicillinase-producing E. coli was as strong as against non-penicillinase-producing E. coli. These results indicate that the ...Continue Reading

References

Jan 1, 1977·European Journal of Biochemistry·B G Spratt
Sep 1, 1977·Antimicrobial Agents and Chemotherapy·W Zimmermann, A Rosselet
Nov 1, 1979·Antimicrobial Agents and Chemotherapy·T KamimuraS Kuwahara
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·B G Spratt
Aug 15, 1975·European Journal of Biochemistry·R A Laskey, A D Mills
Nov 15, 1973·Journal of Molecular Biology·U K Laemmli, M Favre
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey

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Citations

Apr 1, 1983·European Journal of Clinical Microbiology·H LodeP Koeppe
Dec 1, 1990·Antimicrobial Agents and Chemotherapy·F IkedaM Tatsuta
Aug 1, 1988·Journal of Pharmaceutical Sciences·D A LernerM Simeon de Buochberg
May 31, 1988·American Journal of Surgery·H C Neu
Oct 14, 2014·Diagnostic Microbiology and Infectious Disease·Christine RahmeThomas P Lodise

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