Differences between intraoperative ultrasound-based dosimetry and postoperative computed tomography-based dosimetry for permanent interstitial prostate brachytherapy

Brachytherapy
Hiromichi IshiyamaKazushige Hayakawa

Abstract

To compare the results of intraoperative ultrasound (US)-based dosimetry with those of postimplant computed tomography (CT)-based dosimetry after (125)I prostate brachytherapy. Subjects comprised 160 patients who underwent prostate brachytherapy using (125)I seed implants. Prescribed dose was set as 145 Gy to the periphery of the prostate. Implantation was performed using an intraoperative interactive technique. Postimplant dosimetry was performed on Days 1 and 30 after implantation using CT. Dosimetric results for the prostate, urethra, and rectum were compared among intraoperative US and CT on Day 1 (CT(1)) and Day 30 (CT(30)). Mean minimal dose received by 90% of prostate volume was 133.7%, 115.6%, and 125.8% of the prescribed dose on US, CT(1), and CT(30), respectively: This value temporarily decreased on Day 1 and increased on Day 30. Other parameters for the prostate and urethra showed similar trends. Conversely, mean rectal volume receiving 100% of the prescribed dose was 0.69, 0.46, and 1.02 mL on US, CT(1), and CT(30), respectively. Rectal parameters tended to be underestimated on US relative to CT(30)-based dosimetry. A positive linear relationship was identified between US and CT observations for every prostate param...Continue Reading

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Citations

Apr 25, 2013·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Loredana G Marcu, Raghu Gowda
May 9, 2012·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Rajat J KudchadkerSteven J Frank
Apr 26, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J Crook
Sep 10, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Max PetersMarco van Vulpen
Jun 22, 2016·International Journal of Radiation Oncology, Biology, Physics·Hendrik WestendorpAndré W Minken

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