Differences between male and female responses to painful thermal and mechanical stimulation of the human esophagus

Digestive Diseases and Sciences
Jan PedersenAsbjørn Mohr Drewes

Abstract

It is uncertain to what degree sensation and pain relating to the gut are influenced by sex. The aim of the study was to explore sex differences to experimental multimodal stimulation of the esophagus in 22 age-matched males and females. A probe was positioned in the lower part of the esophagus. Mechanical stimuli were applied as distensions with a bag using an impedance planimetric method. The distensions were done before and after relaxation of the smooth muscle. Thermal stimulation was done with recirculating water at 1 and 60 degrees C in the bag. The sensory intensities were assessed during the stimulations, and the referred pain area was drawn at maximum pain intensities. An increased sensation to mechanical stimuli was found in the males for volume, pressure, and tension (P = 0.003, P = 0.02, P = 0.005), whereas cross-sectional area and strain showed no sex difference (P = 0.06, P = 0.9). Sex differences were not found for the cold and warmth stimulations (P = 0.6, P = 0.1). The mean size of the referred pain areas to the different stimuli was 23.6 cm2 in males and 48.7 cm2 in females (P = 0.002). As strain is believed to be the major determinant for the sensory response to mechanical stimulation of the gut, we conclude ...Continue Reading

Citations

Oct 22, 2005·Digestive Diseases and Sciences·Hariprasad ReddyAsbjørn Mohr Drewes
Apr 25, 2006·Inflammatory Bowel Diseases·Asbjørn Mohr DrewesHans Gregersen
Jul 21, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B BanerjeeJ N Sengupta
Nov 17, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D LiaoH Gregersen
Jul 5, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A L KrarupM Simrén
Sep 4, 2010·European Journal of Pain : EJP·Jens Brøndum FrøkjærAsbjørn Mohr Drewes
Apr 25, 2006·Neuroscience·S A K SamiA M Drewes
May 5, 2016·Gastroenterology·Lesley A HoughtonBrenda Toner
Apr 11, 2013·Molecular Pain·Hiroe SatoAsbjørn Mohr Drewes
Apr 3, 2018·Journal of Neurogastroenterology and Motility·Hans Gregersen, Kar Man Lo
Jul 20, 2006·Digestive Diseases·Daniel Sifrim, Kathleen Blondeau
Jul 20, 2006·Digestive Diseases·Hans GregersenDonghua Liao
Apr 25, 2007·Scandinavian Journal of Gastroenterology·Hariprasad ReddyPeter Funch-Jensen
Apr 26, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Peter BanovcinMarian Kollarik
Jul 30, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fei RuMarian Kollarik
May 12, 2006·World Journal of Gastroenterology : WJG·Asbjorn Mohr Drewes, Hans Gregersen

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