Differences between middle cerebral artery blood velocity waveforms of young and postmenopausal women

Menopause : the Journal of the North American Menopause Society
Alykhan KurjiMarc J Poulin

Abstract

We characterized middle cerebral artery (MCA) blood flow velocity waveforms measured by transcranial Doppler ultrasonography in premenopausal (26.6 +/- 6.1 years, mean +/- SD) and postmenopausal (54.0 +/- 3.6 years) women, of whom six were receiving hormone therapy (PM-HT) and seven were not (PM-non-HT). We hypothesized that feature points on MCA waveforms are altered in postmenopausal women compared with those in young women. A short protocol involved maintaining end-tidal PO2 at euoxia (88 mm Hg) and end-tidal PCO2 at 1.5 mm Hg above eucapnic values using a dynamic end-tidal forcing system. Doppler data for the velocity spectral outline (Vp) were collected every 10 ms, and velocity waveform analyses were done on a beat-by-beat basis. Waveform features were identified over each cardiac cycle, including the average Vp (VCYC), maximum acceleration (AMAX), and the ratio of the velocity at the reflected wave and the velocity at peak systole (VR:VMAX). VCYC was unchanged between premenopausal and postmenopausal women (69.4 +/- 9.6 and 67.5 +/- 11.1 cm/s, respectively). AMAX was significantly higher (P = 0.007) in premenopausal women (987.9 +/- 280.7 cm/s) compared with postmenopausal women (743.1 +/- 100.3). Conversely, VR:VMAX was...Continue Reading

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Citations

Sep 2, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Ming Zhang, Mustafa Akbulut
Dec 28, 2007·Ultrasound in Medicine & Biology·Jason W RobertsonMarc J Poulin
Nov 7, 2019·Menopause : the Journal of the North American Menopause Society·Áine BrislaneNicola D Hopkins
Nov 6, 2018·Frontiers in Neurology·Samuel G ThorpeRobert B Hamilton
Oct 8, 2018·Translational Stroke Research·Samuel G ThorpeRobert B Hamilton
Jul 22, 2021·Scientific Reports·Rashid AfkhamiSarah J Johnson

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