PMID: 8607999Apr 1, 1996Paper

Differences between somatic and dendritic inhibition in the hippocampus

Neuron
R MilesT F Freund

Abstract

Hippocampal synaptic inhibition is mediated by distinct groups of inhibitory cells. Some contact pyramidal cells perisomatically, while others terminate exclusively on their dendrites. We examined perisomatic and dendritic inhibition by recording from CA3 inhibitory and pyramidal cells and injecting biocytin to visualize both cells in light and electron microscopy. Single perisomatic inhibitory cells made 2-6 terminals clustered around the soma and proximal pyramidal cell processes. Dendritic cells established 5-17 terminals, usually on different dendrites of a pyramidal cells. Perisomatic terminals were larger than those facing dendritic membrane. Perisomatic inhibitory cells initiated the majority of simultaneous IPSPs seen in nearby pyramidal cells. Single IPSPs initiated by perisomatic sodium-dependent action potentials. Activation of inhibitory fibers terminating on dendrites could suppress calcium-dependent spikes. Thus, distinct inhibitory cells may differentially control dendritic electrogenesis and axonal output of hippocampal pyramidal cells.

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Citations

Jan 1, 1996·Hippocampus·P S Buckmaster, I Soltesz
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
May 15, 1998·Hippocampus·F J Martínez-GuijarroJ R Alonso
Jan 17, 2002·The Journal of Comparative Neurology·Yuri GoncharAndreas Burkhalter
May 3, 2005·Psychopharmacology·Alessandro GuidottiErminio Costa
Dec 3, 2008·Experimental Brain Research·J T H TeoJ C Rothwell
Jan 2, 2007·Journal of Neural Transmission·S BrummelteG Teuchert-Noodt
Feb 24, 2010·Journal of Computational Neuroscience·Peter JedlickaStephan W Schwarzacher
Feb 6, 2004·Progress in Neurobiology·Rafael Gutiérrez
Jun 2, 2005·Regulatory Peptides·Malin KimEric Hanse
Oct 3, 2003·Trends in Neurosciences·Gianmaria Maccaferri, Jean-Claude Lacaille
Mar 30, 2004·Trends in Neurosciences·György BuzsákiXiao-Jing Wang
Sep 3, 2002·Neuroscience and Biobehavioral Reviews·Peter J MorganeJanina R Galler
May 4, 2001·Brain Research. Developmental Brain Research·J L GaïarsaY Ben-Ari
Nov 14, 2000·Trends in Neurosciences·Y Ben-Ari, R Cossart
Oct 24, 2002·Trends in Neurosciences·Jean-Luc GaiarsaYehezkel Ben-Ari
Sep 2, 2003·Trends in Neurosciences·David D Mott, Raymond Dingledine
Sep 2, 2003·Trends in Neurosciences·Tamás F Freund
Mar 1, 1997·Trends in Neurosciences·G StuartM Häusser
Nov 19, 1997·Trends in Neurosciences·Y Ben-AriJ L Gaiarsa
Jul 22, 1998·Progress in Neurobiology·D A TurnerR Nitsch
Mar 26, 2002·Neuroscience Letters·Maksim V StorozhukPlaton G Kostyuk

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