Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type-1 receptor expression

The American Journal of Pathology
H Takeda, S Kondo

Abstract

Angiotensin II receptors are the specific receptors of angiotensin II of the renin-angiotensin system. The existence and role of the receptors in the skin have not been determined. We immunohistochemically studied the expression of angiotensin receptors in the human skin. The results demonstrated the expression of angiotensin type 1 receptor (AT1) in the normal human suprabasal epidermis. The expression pattern suggests the role of AT1 in association with differentiation. In addition, we studied the expression of AT1 in squamous cell carcinoma (SCC) of the skin, SCC of the lip, and keratoacanthoma (KA). Our experiments showed that high, intermediate, and low levels of AT1 were observed in 37 (74.0%), 7 (14.0%), and 2 (4.0%) of 50 cases of SCC of the skin, respectively, and the negative periphery pattern was observed in 17 (77.3%) of 22 cases of KA. These observations suggest that the immunohistochemical study of AT1 is useful to distinguish SCC from KA. Studying the role and distribution of AT1 may help in understanding the pathophysiology of the skin.

References

May 15, 1991·Biochemical and Biophysical Research Communications·H ItohV J Dzau
Aug 30, 1996·Molecular and Cellular Endocrinology·S MeffertT Unger
Dec 4, 1996·Biochemical and Biophysical Research Communications·U M SteckelingsB M Henz
Feb 1, 1997·Annals of Medicine·K HelinT Unger
May 9, 1997·Neuroscience Letters·S GallinatT Unger

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Citations

Oct 23, 2010·Nature Reviews. Cancer·Amee J GeorgeRoss D Hannan
Feb 12, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Robert A Schwartz
Apr 9, 2005·Journal of Inflammation·Gary Robert Smith, Sotiris Missailidis
Feb 11, 2012·Molecular Endocrinology·Rekha YesudasThomas Thekkumkara
Mar 1, 2006·Expert Opinion on Biological Therapy·Kazuhiko InoFumitaka Kikkawa
Feb 9, 2016·Journal of the American Academy of Dermatology·Bartlomiej Kwiek, Robert A Schwartz
Feb 16, 2013·Néphrologie & thérapeutique·Cécile Vigneau, Nathalie Rioux-Leclercq
Jan 22, 2013·Néphrologie & thérapeutique·Thibault Dolley-HitzeCécile Vigneau
Mar 24, 2016·Cancer Letters·Ying LiuTian-Rui Xu
Jan 31, 2006·Journal of the American Academy of Dermatology·Kiyoshi MoriharaSaburo Kishimoto
Aug 3, 2005·Trends in Endocrinology and Metabolism : TEM·Frédérique Deshayes, Clara Nahmias
May 20, 2015·European Journal of Pharmacology·Anukriti SinghBushra Ateeq
Jan 24, 2009·International Journal of Cancer. Journal International Du Cancer·Natasa VasiljevićOla Forslund
Feb 25, 2014·Clinical Science·Claudio M Costa-NetoLucas T Parreiras-E-Silva
Feb 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Oscar ArrietaArmando Gamboa-Domínguez
May 29, 2004·American Journal of Obstetrics and Gynecology·Fumitaka KikkawaShigehiko Mizutani
Jan 17, 2015·International Journal of Colorectal Disease·W Kurtis Childers
Jul 12, 2014·Gynecologic Oncology·Young-Ae ParkByoung-Gie Kim
Feb 28, 2004·Experimental Dermatology·U Muscha SteckelingsMetin Artuc
Mar 17, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Silvana Aparecida Alves CorrêaIsmael Dale Cotrim Guerreiro da Silva
Oct 18, 2006·The Prostate·Takeo KosakaMasamichi Hayakawa
Mar 3, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kiyosumi ShibataShigehiko Mizutani
Jul 7, 2007·International Journal of Dermatology·Amel Karaa, Amor Khachemoune
Apr 3, 2009·Journal of Human Hypertension·T Rosenthal, I Gavras
Feb 21, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thomas C PuttiYoke S Lee
Apr 10, 2012·Archives of Gynecology and Obstetrics·Qing YangRina Sa

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