Differences between target and non-target probe processing--combined evidence from fMRI, EEG and fMRI-constrained source analysis

NeuroImage
Daniela GalashanManfred Herrmann

Abstract

Previous studies reported heterogeneous findings in working memory tasks when examining differences between correct recognition (targets) and correct rejection (non-targets). In the present study, twenty human participants completed a delayed match-to-sample task in two separate functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) sessions. Targets and non-target items were presented at different within-trial positions. We used fMRI-constrained source analysis to investigate the spatio-temporal neuronal dynamics of probe processing. Probe type-related differences were modulated by position in the trial or by the ratio of target stimuli to non-target stimuli at different trial positions. fMRI-constrained source analysis revealed a temporal pattern of source activities starting in occipital and temporal brain regions, followed by a simultaneous engagement of parietal and frontal brain regions and a later activity of a source in pre-SMA (supplementary motor area). Source activities demonstrated a specific involvement of left fusiform gyrus in the non-target condition compared to the target condition that might be associated with mental imagination of the target stimulus during non-target probe processing. ...Continue Reading

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Citations

Jun 14, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Birgit MathesCanan Basar-Eroglu

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