PMID: 2125542Jan 1, 1990Paper

Differences between the effects of EDTA and citrate anticoagulants on platelet count and mean platelet volume

Clinical and Laboratory Haematology
R L McShineB Brozovic

Abstract

Platelet counts on whole blood samples collected into tripotassium salt of EDTA, trisodium citrate (Na3 citr), citrate phosphate dextrose adenine formula 1 (CPDA-1) and acid citrate dextrose formula A (ACD-A), all showed a statistically significant drop (P less than 0.01) after 1 h standing at room temperature (RT) as compared with the immediate (within 30 min) counts. After 1 h the enumeration became stable in the EDTA samples but the drop continued up to 4-6 h in those samples taken into citrate. The decreases in citrate were significant (18-30%, P less than 0.001). The addition of EDTA (1.5 mg/ml) to the citrated samples after the sixth hour count created a significant rise (6-22%, P less than 0.01) in the counts between the sixth and the seventh hour. Our observations show that platelet counts in citrated blood samples are lower than those in EDTA and highlight the necessity to present citrated samples mixed wtih dried EDTA when characterization or quality control of blood and blood components is required. Analysis of the mean platelet volume (MPV) showed significantly lower values (6-13%, P less than 0.05) in the citrated samples as compared to the same samples in EDTA, and a significant increase (4-6%, P less than 0.01) o...Continue Reading

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Citations

Jan 1, 1995·Journal of Clinical Laboratory Analysis·P PignatelliP P Gazzaniga
Apr 25, 2001·Clinical and Laboratory Haematology·J L RitchieI M Rea
Aug 1, 2012·Polish Journal of Veterinary Sciences·M ZmigrodzkaM Guzera
Jul 3, 2013·Internal Medicine·Takatoshi KitazawaHiroshi Yotsuyanagi
Feb 26, 2020·Blood Advances·Leslie SkeithTheodore E Warkentin
Jan 1, 1991·Clinical and Laboratory Haematology·W GoossensR L Verwilghen
Jan 1, 1996·Journal of Clinical Laboratory Analysis·P PignatelliP P Gazzaniga
Oct 14, 2014·Veterinary Surgery : VS·Caitlin M O'SheaLinda A Dahlgren
Mar 18, 2017·International Journal of Laboratory Hematology·G KecskemétinéA H Shemirani
May 20, 2020·International Journal of Molecular Sciences·Teresa L KrammerMatthias Hackl
Sep 1, 2020·PloS One·Heather Wilson-RoblesGaetan Michel
Sep 1, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Marcus D LancéMarco A E Marcus
Dec 17, 2015·Scientific Reports·I Re LeeJi Hong Kim
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·R D McBaneW G Owen
Sep 14, 2016·Scientific Reports·Adam J MitchellCharles D Searles
Dec 16, 2017·Angiology·Bartosz HudzikBarbara Zubelewicz-Szkodzińska
Oct 28, 2019·Platelets·Farzaneh SadeghiAmir Houshang Shemirani
Sep 18, 2014·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Ahmad OryanAbdolhamid Meimandi-Parizi

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