PMID: 7019447Feb 1, 1981Paper

Differences between the events preceding spina bifida and anencephaly

Journal of Medical Genetics
W H James

Abstract

It is usually held that there is a time continuum in the formation of monoxygotic (MZ) twins which is indexed by their placentation, running from dichorionic to monochorionic diamniotic to monochorionic monoamniotic and conjoined pairs. There is good evidence that this continuum is characterised by a continuum of predisposition to anencephaly, slightly raised in dichorionic pairs but very high in some sorts of conjoined pairs. Although MZ twins, especially monoamniotic and conjoined pairs, are peculiarly liable to anencephaly, they are not particularly susceptible to spina bifida. Among twin pairs concordant for anencephaly or spina bifida, there are strikingly few concordant in the sense of one twin having anencephaly and the other spina bifida, in contrast with the numbers of pairs concordant for the same malformation. The prevalence of anencephaly in double monsters varies with the type of monster, being high in diprosopus. These findings may be explained by the timing of embryonic events.

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Citations

Sep 6, 1986·Lancet·W H James
Oct 11, 2011·Human Reproduction·I Ben-AmiR Maymon
Dec 19, 1987·British Medical Journal·E Hare
Jan 1, 2013·Reproductive Biomedicine Online·E JauniauxR Maymon
Oct 22, 2008·Taiwanese Journal of Obstetrics & Gynecology·Chih-Ping Chen
Jun 1, 1987·Experimental Neurology·L R CampbellG S Sohal
Jun 27, 2003·Environmental Health Perspectives·Todd R Sandrin, Raina M Maier
Dec 1, 1985·Journal of Medical Genetics·K M LaurenceC J Roberts
Jan 1, 1982·Acta geneticae medicae et gemellologiae·G C WindhamL E Sever
Jan 1, 1987·Acta geneticae medicae et gemellologiae·C E Boklage
Jul 27, 2021·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Jenny van DongenNicholas G Martin

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