Differences in acidosis-stimulated renal ammonia metabolism in the male and female kidney

American Journal of Physiology. Renal Physiology
Autumn N HarrisI David Weiner

Abstract

Renal ammonia excretion is a critical component of acid-base homeostasis, and changes in ammonia excretion are the predominant component of increased net acid excretion in response to metabolic acidosis. We recently reported substantial sex-dependent differences in basal ammonia metabolism that correlate with sex-dependent differences in renal structure and expression of key proteins involved in ammonia metabolism. The purpose of the present study was to investigate the effect of sex on the renal ammonia response to an exogenous acid load. We studied 4-mo-old C57BL/6 mice. Ammonia excretion, which was less in male mice under basal conditions, increased in response to acid loading to a greater extent in male mice, such that maximal ammonia excretion did not differ between the sexes. Fundamental structural sex differences in the nonacid-loaded kidney persisted after acid loading, with less cortical proximal tubule volume density in the female kidney than in the male kidney, whereas collecting duct volume density was greater in the female kidney. To further investigate sex-dependent differences in the response to acid loading, we examined the expression of proteins involved in ammonia metabolism. The change in expression of phosph...Continue Reading

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Citations

Mar 3, 2020·American Journal of Physiology. Renal Physiology·Autumn N HarrisI David Weiner
Sep 29, 2020·American Journal of Physiology. Renal Physiology·Dominique M BoveeEwout J Hoorn
Dec 15, 2020·American Journal of Physiology. Renal Physiology·Autumn N Harris, I David Weiner
Oct 12, 2020·Biochemical Pharmacology·Bianca N QuadeRossana Occhipinti
Mar 30, 2021·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Oct 5, 2021·American Journal of Physiology. Renal Physiology·Autumn N HarrisI David Weiner

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