Differences in activation of aryl hydrocarbon receptors of white sturgeon relative to lake sturgeon are predicted by identities of key amino acids in the ligand binding domain

Environmental Science & Technology
Jon A DoeringMarkus Hecker

Abstract

Dioxin-like compounds (DLCs) are pollutants of global environmental concern. DLCs elicit their adverse outcomes through activation of the aryl hydrocarbon receptor (AhR). However, there is limited understanding of the mechanisms that result in differences in sensitivity to DLCs among different species of fishes. Understanding these mechanisms is critical for protection of the diversity of fishes exposed to DLCs, including endangered species. This study investigated specific mechanisms that drive responses of two endangered fishes, white sturgeon (Acipenser transmontanus) and lake sturgeon (Acipenser fulvescens) to DLCs. It determined whether differences in sensitivity to activation of AhRs (AhR1 and AhR2) can be predicted based on identities of key amino acids in the ligand binding domain (LBD). White sturgeon were 3- to 30-fold more sensitive than lake sturgeon to exposure to 5 different DLCs based on activation of AhR2. There were no differences in sensitivity between white sturgeon and lake sturgeon based on activation of AhR1. Adverse outcomes as a result of exposure to DLCs have been shown to be mediated through activation of AhR2, but not AhR1, in all fishes studied to date. This indicates that white sturgeon are likely t...Continue Reading

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Citations

Sep 30, 2016·Environmental Science & Technology·Hui PengAndrew Emili
May 20, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Erica K BrockmeierFrancesco Falciani
Jan 20, 2018·Environmental Toxicology and Chemistry·Cynthia D FranciJessica A Head
May 18, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jon A DoeringGerald T Ankley
May 28, 2019·Environmental Toxicology and Chemistry·Edward J PerkinsStefan Scholz
Dec 20, 2019·Environmental Science & Technology·Libe Aranguren-AbadíaOdd André Karlsen

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