Differences in adipocyte long chain fatty acid uptake in Osborne-Mendel and S5B/Pl rats in response to high-fat diets

International Journal of Obesity : Journal of the International Association for the Study of Obesity
O PetrescuP D Berk

Abstract

To determine whether strain differences in adipocyte uptake of long chain fatty acids (LCFAs) contribute to differences in weight gain by Osborne-Mendel (OM) and S5B/Pl rats (S) fed a high-fat diet (HFD). Ninety-four adult (12-14-week old) male OM and S rats. Body weight; epididymal fat pad weight; adipocyte size, number, LCFA uptake kinetics; and plasma insulin and leptin during administration of HFD or chow diets (CDs). In both strains, rate of weight gain (RWG) was greater on an HFD than a CD; RWG on an HFD was greater, overall, in OM than S. A significant RWG increase occurred on days 1 and 2 in both strains. It was normalized in S by days 6-9 but persisted at least till day 14 in OM. RWGs were significantly correlated (P<0.001) with the V(max) for saturable adipocyte LCFA uptake (V(max)). In S, an increase in V(max) on day 1 returned to baseline by day 7 and was correlated with both plasma insulin and leptin levels throughout. In OM, a greater increase in V(max) was evident by day 2, and persisted for at least 14 days, during which both insulin and leptin levels remained elevated. Growth in epididymal fat pads on the HFD correlated with body weight, reflecting hypertrophy in OM and both hypertrophy and hyperplasia in S. (a...Continue Reading

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Citations

Apr 21, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S D PrimeauxG A Bray
Feb 27, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christy L WhiteChristopher D Morrison
Dec 8, 2015·Canadian Journal of Physiology and Pharmacology·Timothy D Allerton, Stefany D Primeaux
Nov 21, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J M PoretS D Primeaux
Oct 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul D Berk
Oct 25, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christina S-Y ChenStefany D Primeaux
Mar 13, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Hüseyin AbdikFikrettin Şahin

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