Differences in age-dependent neural correlates of semantic processing between youths with autism spectrum disorder and typically developing youths

Autism Research : Official Journal of the International Society for Autism Research
Pin-Jane ChenTai-Li Chou

Abstract

Individuals with autism spectrum disorders (ASD) have aberrant neural activity during semantic judgments. We aimed to examine age-dependent neural correlates of semantic processing in boys with ASD as compared to typically developing boys (TD). We used functional MRI to investigate 37 boys with ASD (mean age = 13.3 years, standard deviation = 2.4) and 35 age-, sex-, Intelligence quotient (IQ)- and handedness-matched TD boys (mean age = 13.3 years, standard deviation = 2.7) from age 8 to 18 years. Participants had to indicate whether pairs of Chinese characters presented visually were related in meaning. Group (ASD, TD) × Age (Old, Young) ANOVA was used to examine the difference of age-related changes. Direct comparisons between the adolescent group and the child group were also performed. The behavioral results showed that the ASD group had lower accuracy in the related condition relative to the TD group. The neuroimaging results showed greater activation in the cuneus and less activation in the left inferior frontal gyrus in boys with ASD than TD boys. Children with ASD produced greater activation in the cuneus than TD children. Adolescents with ASD showed reduced left IFG activation as compared to TD adolescents. Our findings...Continue Reading

References

Jun 24, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·Ovsanna Tadevosyan-LeyferSusan E Folstein
Aug 7, 2004·Cerebral Cortex·Timothy T BrownBradley L Schlaggar
Jan 18, 2005·NeuroImage·Hideya KoshinoMarcel Adam Just
Jul 5, 2005·The American Journal of Psychiatry·Susan S F GauAndrew T A Cheng
Aug 27, 2005·Journal of Autism and Developmental Disorders·Michelle A Dunn, Juliana C Bates
Nov 9, 2005·NeuroImage·Tai-Li ChouNadia E Cone
Feb 24, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Sarah-Jayne Blakemore, Suparna Choudhury
Apr 7, 2006·Brain : a Journal of Neurology·M-J CaronM Dawson
Jul 13, 2006·Brain : a Journal of Neurology·Rajesh K KanaMarcel Adam Just
Oct 29, 2008·Journal of the International Neuropsychological Society : JINS·Tracey A KnausHelen Tager-Flusberg
Feb 8, 2011·Epilepsy & Behavior : E&B·Kwang Ki KimJerzy P Szaflarski
Apr 6, 2011·Human Brain Mapping·Fabienne SamsonThomas A Zeffiro
Feb 18, 2012·Developmental Cognitive Neuroscience·Shu-Hui LeeTai-Li Chou
Mar 16, 2013·Autism Research : Official Journal of the International Society for Autism Research·Diane L WilliamsMarcel Adam Just
Jul 16, 2013·Autism Research : Official Journal of the International Society for Autism Research·Yu-Chun LoWen-Yih Isaac Tseng
Oct 1, 2013·Lancet·Meng-Chuan LaiSimon Baron-Cohen
Dec 3, 2014·Journal of Psycholinguistic Research·Meng-Feng LiJei-Tun Wu

❮ Previous
Next ❯

Citations

Aug 7, 2019·Autism Research : Official Journal of the International Society for Autism Research·Ciao-Han WongTai-Li Chou
Feb 6, 2021·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Li-Ying FanSusan Shur-Fen Gau
Apr 9, 2021·Frontiers in Neuroscience·Zhihong LanTianyue Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

Autism Research : Official Journal of the International Society for Autism Research
Abbey J HerringshawRajesh K Kana
Autism Research : Official Journal of the International Society for Autism Research
Hsiang-Yun ChienWen-Yih Isaac Tseng
Autism Research : Official Journal of the International Society for Autism Research
Donna L MurdaughRajesh K Kana
© 2022 Meta ULC. All rights reserved