PMID: 9161710May 1, 1997Paper

Differences in aldehyde oxidase activity in cytosolic preparations of human and monkey liver

Biochemistry and Molecular Biology International
K SugiharaK Dohi

Abstract

This study presents data showing individual differences in aldehyde oxidase activity in human and monkey liver cytosols. When assayed with benzaldehyde as a substrate, a significant inter-subject variation in the activity was found in the human liver preparations. When assayed with N1-methylnicotinamide as a substrate, the inter-subject variation of the activity was also observed, but to a lesser extent compared with that of the activity with benzaldehyde. Similarly, variations in aldehyde oxidase activity were found in the monkey liver preparations when assayed with benzaldehyde or N1-methylnicotinamide. The present study suggested that at least two isozymes of aldehyde oxidase exist in the human liver preparations.

Citations

Oct 26, 2000·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·K SugiharaH Shintani
May 21, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·S KitamuraS Ohta
Aug 6, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·H S Al-Salmy
Feb 28, 2016·Archives of Toxicology·Mineko TeraoEnrico Garattini
Jun 9, 2009·Alimentary Pharmacology & Therapeutics·M A SmithJ D Sanderson
May 17, 2006·Drug Metabolism and Pharmacokinetics·Shigeyuki KitamuraShigeru Ohta
Jan 16, 2007·Drug Metabolism and Pharmacokinetics·Aya MoriyasuShigeyuki Kitamura
May 15, 2007·Drug Metabolism and Pharmacokinetics·Yoshitaka TayamaShigeyuki Kitamura
Mar 29, 2012·Drug Metabolism and Pharmacokinetics·Yoshitaka TayamaShigeru Ohta
Jan 18, 2017·Expert Opinion on Drug Discovery·Mohammad-Reza Rashidi, Somaieh Soltani
Mar 8, 2020·The Journal of Biological Chemistry·Mineko TeraoSilke Leimkühler
Mar 20, 2010·Pharmacogenomics·Melissa A SmithJeremy D Sanderson
Feb 18, 2012·Expert Opinion on Drug Metabolism & Toxicology·Enrico Garattini, Mineko Terao
Jan 30, 2021·The Journal of Biological Chemistry·Mineko TeraoSilke Leimkühler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.