PMID: 7515857Feb 1, 1994Paper

Differences in altered expression of L-selectin and Mac-1 in monocytes and neutrophils

Inflammation
J Lundahl, J Hed

Abstract

We have measured the altered expression of the adhesion-promoting glucoproteins L-selectin and Mac-1 on monocytes and neutrophils after incubation with different concentrations of the chemotactic factor FMLP. We found a time- and dose-related down-regulation of L-selectin on both monocytes and neutrophils, which was more pronounced on neutrophils as compared to monocytes at both low (10(-12) M) and high (10(-7) M) concentrations of the chemotactic factor FMLP. Presence of human albumin reduced the down-regulation of L-selectin on both monocytes and neutrophils but to a greater extent on monocytes. Mac-1 expression increased in a time and dose-dependent manner on both monocytes and neutrophils when they were incubated with both low (10(-12) M) and high (10(-7) M) concentrations of FMLP, but the expression was more pronounced on neutrophils. The up-regulation of Mac-1 was equally reduced by albumin on monocytes and neutrophils. Presence of EDTA in RPMI medium reduced the FMLP-induced down-regulation of L-selectin on both monocytes and neutrophils, indicating that the down-regulation of L-selectin is partly divalent cation dependent. Differences in the altered expression of L-selectin and Mac-1 in monocytes and neutrophils with su...Continue Reading

References

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Citations

Nov 26, 2002·Journal of Immunological Methods·Sandra J GallagherElizabeth M Wagner
Jul 25, 2000·Immunopharmacology·A Sahu, J D Lambris
Feb 14, 2002·Resuscitation·Timothy H Rainer
Oct 28, 2003·American Journal of Respiratory Cell and Molecular Biology·Yukinobu GotoStephan F Van Eeden
Jun 14, 2002·Biochimica Et Biophysica Acta·I Maria LindmarkOliver Nüsse
Nov 20, 1998·Clinical and Experimental Immunology·A C Muller KoboldJ W Tervaert

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