Differences in amyloid deposition in primary and recurrent corneal lattice dystrophy type 1

Cornea
David R J Snead, B Non Mathews

Abstract

To report the histopathology of a case of recurrent corneal lattice dystrophy showing altered distribution of the corneal deposits in the recurrent disease compared with the original. Clinical details and histopathology of the primary and repeat corneal grafts are reported. A woman originally presented at age 28 years with reduced visual acuity and classic corneal lattice lines in both corneas and underwent bilateral corneal grafts. Recurrent disease was detected 20 years later as anterior haze and various-sized subepithelial opacities but no stromal lattice lines. Histology of the original corneas demonstrated amyloid deposits throughout the corneal stroma, typical of corneal lattice dystrophy. In the repeat grafts, amyloid deposits were confined to the basement membrane region of the anterior cornea and were almost entirely absent from the stroma of the cornea. Recurrence of corneal lattice dystrophy is widely recognized to occur, but the pathology of the recurrent disease is not well documented in the literature. This case report highlights that there may be a difference in the distribution of the deposits when the disease recurs. We postulate that the reason for this difference may be that donor keratocytes survive long eno...Continue Reading

References

Feb 1, 1984·American Journal of Ophthalmology·D M Meisler, M Fine
Oct 1, 1982·American Journal of Ophthalmology·G K KlintworthJ Reed
Mar 1, 1997·Nature Genetics·F L MunierD F Schorderet
Oct 21, 1998·American Journal of Ophthalmology·M OkadaY Tano

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Citations

Apr 8, 2009·Cornea·Jayne S WeissGordon K Klintworth
Jul 24, 2014·Cornea·Walter Lisch, Berthold Seitz
Jun 12, 2010·Experimental Eye Research·Enzo Di IorioStefano Ferrari

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