Differences in antigenic structure of inactivated poliovaccines made from Sabin live-attenuated and wild-type poliovirus strains: impact on vaccine potency assays

The Journal of Infectious Diseases
Laura CrawtsIPV Study Group

Abstract

Following the declaration of wild poliovirus type 2 eradication in 2015, the type 2 component was removed from the live-attenuated oral polio vaccine (OPV). This change implies a need to improve global coverage of routine immunization with inactivated polio vaccine (IPV) to ensure type 2 immunity. Several manufacturers use Sabin-OPV strains for IPV production (sIPV) rather than the usual wild-type strains used for conventional IPV (cIPV). However, contrarily to cIPV, potency assays for sIPV have not been standardized, no international references exist and no antigen units have been defined for a sIPV human dose. Thus, sIPV products from different manufacturers cannot be compared and the relationship between antigenicity and immunogenicity of sIPV is not well understood. A collaborative study was conducted in which laboratories used different methods to measure the antigen content of a set of sIPV and cIPV samples with an aim to identify a suitable reference for sIPV products. The study revealed differences in the reactivity of antibody reagents with cIPV and sIPV products. Homologous references are required to measure the antigen content of IPV products consistently. The 1 st WHO International Standard for sIPV was established ...Continue Reading

References

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Aug 5, 2014·Vaccine·Haruko ShiratoUNKNOWN sIPV Evaluation Group of NIID-Virology II
Oct 16, 2014·The Journal of Infectious Diseases·Cara C BurnsOlen M Kew
Sep 24, 2016·The Journal of Infectious Diseases·Guoyang LiaoQihan Li
Oct 11, 2016·Biologicals : Journal of the International Association of Biological Standardization·Hiromasa OkayasuRoland W Sutter

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