Differences in antigenicity of E2 in Semliki Forest virus particles and in infected cells

Archives of Virology
S Repges-Illguth, G Kaluza

Abstract

Using six monoclonal antibodies to epitopes a-f on the glycoprotein E2 of Semliki Forest virus (SFV) we found antigenic differences between E2 in infected cells and in virus particles, respectively, if glycosylation was impaired by 2-deoxy-D-glucose or inhibited by N-methyl-1-deoxynojirimycin. Furthermore we concluded that a conformational change of E2 takes place on virus budding.

References

Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I de Curtis, K Simons
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J J SkehelD C Wiley

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Citations

Jul 18, 2002·Nature Reviews. Drug Discovery·Raymond A DwekNicole Zitzmann

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