Differences in atypical resting-state effective connectivity distinguish autism from schizophrenia

NeuroImage. Clinical
Dana MastrovitoStephen Jose Hanson

Abstract

Autism and schizophrenia share overlapping genetic etiology, common changes in brain structure and common cognitive deficits. A number of studies using resting state fMRI have shown that machine learning algorithms can distinguish between healthy controls and individuals diagnosed with either autism spectrum disorder or schizophrenia. However, it has not yet been determined whether machine learning algorithms can be used to distinguish between the two disorders. Using a linear support vector machine, we identify features that are most diagnostic for each disorder and successfully use them to classify an independent cohort of subjects. We find both common and divergent connectivity differences largely in the default mode network as well as in salience, and motor networks. Using divergent connectivity differences, we are able to distinguish autistic subjects from those with schizophrenia. Understanding the common and divergent connectivity changes associated with these disorders may provide a framework for understanding their shared cognitive deficits.

References

Jan 1, 1988·Schizophrenia Bulletin·R L MorrisonK T Mueser
Jan 1, 1987·Psychopathology·J CuttingD Murphy
Oct 1, 1972·Journal of Autism and Childhood Schizophrenia·M Rutter
Apr 1, 1971·The British Journal of Psychiatry : the Journal of Mental Science·I Kolvin
Mar 1, 1996·Brain Research. Cognitive Brain Research·G RizzolattiL Fogassi
Jul 7, 2001·Journal of Autism and Developmental Disorders·M M Konstantareas, T Hewitt
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Apr 22, 2004·Schizophrenia Research·Debra TitoneDeborah L Levy
Sep 8, 2004·Trends in Cognitive Sciences·Vittorio GalleseGiacomo Rizzolatti
Mar 8, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Robert T Schultz
Jul 5, 2005·Brain Research. Cognitive Brain Research·Lindsay M ObermanJaime A Pineda
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Jul 1, 2006·Trends in Neurosciences·Antonio M Persico, Thomas Bourgeron
Oct 19, 2006·Neuroreport·Vladimir L CherkasskyMarcel Adam Just
Dec 26, 2006·Trends in Cognitive Sciences·Randy L Buckner, Daniel C Carroll
Oct 29, 2008·Neuropsychology Review·Lauren KenworthyGregory L Wallace
Nov 6, 2008·Social Cognitive and Affective Neuroscience·Lindsay M ObermanVilayanur S Ramachandran
Jun 30, 2009·Biochimica Et Biophysica Acta·Tania L RothJoel E Kleinman
Nov 19, 2009·Schizophrenia Bulletin·Jazmin CamchongKelvin O Lim
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Bernard CrespiMichael Elliot
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Oct 15, 2010·Cerebral Cortex·Jeffrey S AndersonJanet E Lainhart
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer L Stevenson, Kristina A Kellett
Apr 13, 2011·Journal of Neurodevelopmental Disorders·Noah J SassonAysenil Belger
Jun 23, 2011·Journal of Psychiatry & Neuroscience : JPN·Lena Palaniyappan, Peter F Liddle
Oct 7, 2011·Biological Psychiatry·Peter G EnticottPaul B Fitzgerald
Oct 19, 2011·Brain : a Journal of Neurology·Jeffrey S AndersonJanet E Lainhart
Nov 15, 2011·Brain Connectivity·Jeffrey S AndersonDeborah Yurgelun-Todd
Nov 22, 2011·Neuron·Jonathan D PowerSteven E Petersen
Mar 6, 2012·NeuroImage·Alex FornitoEdward T Bullmore
May 29, 2012·Schizophrenia Research·Archana VenkataramanMarek Kubicki
Aug 13, 2013·PloS One·Emil H J NijhuisDavid G Norris
Oct 5, 2013·Frontiers in Human Neuroscience·Jared A NielsenJeffrey S Anderson
Nov 16, 2013·Trends in Cognitive Sciences·Martijn P van den Heuvel, Olaf Sporns

❮ Previous
Next ❯

Citations

Apr 19, 2018·International Review of Psychiatry·James Harris
Jan 13, 2019·Scientific Reports·Alessandro CrimiDiego Sona
Jun 30, 2019·Frontiers in Neuroscience·Farzad V FarahaniNichole R Lighthall
Jan 31, 2020·Frontiers in Computational Neuroscience·Dennis Joe HarmahPeng Xu
Dec 19, 2018·NeuroImage. Clinical·Stefano DamianiGeorg Northoff
Jun 21, 2021·NeuroImage·Alessandro CrimiDiego Sona
Jul 25, 2021·Sensors·David Ahmedt-AristizabalLars Petersson
Jul 17, 2021·Revista de psiquiatrí́a y salud mental·Pau Soldevila-MatíasBenedicto Crespo-Facorro
Dec 31, 2021·Autism Research : Official Journal of the International Society for Autism Research·Amandeep JutlaJeremy Veenstra-VanderWeele

❮ Previous
Next ❯

Software Mentioned

MCFLIRT
R bnlearn
BrainNet Viewer

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Autism: Treatment Targets

The absence of effective treatments for autism are due to the high clinical and genetic heterogeneity between affected individuals, restricted knowledge of the underlying pathophysiological mechanisms, and the lack of reliable diagnostic biomarkers. Identification of more homogenous biological subgroups is therefore essential for the development of novel treatments based on the molecular mechanisms underpinning autism and autism spectrum disorders. Find the latest research on autism treatment targets here.