PMID: 9174647May 1, 1997Paper

Differences in Ca2+ pumping activity between sub-populations of human red cells

Cell Calcium
P J Romero, E A Romero

Abstract

It has been shown recently that the free Ca2+ content of human red cells rises during ageing in vivo. With the aim of determining the mechanisms involved in such a change, we have investigated some aspects of Ca2+ homeostasis. Both the initial rate of Ca2+ influx and some kinetic parameters of the Ca2+ pump of human red cells were studied in light and dense sub-populations obtained through stringent, self-formed Percoll gradients. At 37 degrees C and pH 7.4, no differences in Ca2+ entry were found. By contrast, either at pH 7.0 or 7.4, the maximal Ca2+ extrusion rate of the approximately 10% heaviest cells was one-half of the corresponding lighter ones. The results demonstrate that the elevated free Ca2+ concentration distinctive of senescent cells, arises from a reduction in Ca2+ extrusion capacity during ageing. The possible physiological significance of this finding is discussed.

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Citations

Dec 7, 2002·Cell Biology International·Pedro J RomeroConcepción Hernández
Jul 25, 2009·The Journal of Membrane Biology·Eneida A RomeroB Eleazar Cohen
Nov 17, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dorota Polak-JonkiszKinga Musiał
May 2, 2007·The Journal of General Physiology·Teresa TiffertVirgilio L Lew
Sep 29, 2011·The Journal of General Physiology·Teresa Tiffert, Virgilio L Lew
Mar 23, 2013·Current Opinion in Hematology·Patrick G Gallagher
Jun 26, 2013·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·E A SkverchinskaiaA V Novozhilov
Jan 25, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Nadezhda N BarvitenkoRoy E Weber
Dec 28, 2006·Cell Biochemistry and Function·Silvana BalzanUmberto Montali
Sep 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Eyup CinarJiandi Wan
Jun 29, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Kitty de Jong, Frans A Kuypers
Dec 22, 1999·Cell Calcium·P J Romero, E A Romero
Jan 23, 2017·Ageing Research Reviews·Gennadii Petrovich GusevNatalia Ivanovna Agalakova
Apr 1, 2017·Bulletin of Experimental Biology and Medicine·E S ShurkhinaV M Nesterenko
May 24, 2013·International Journal of Molecular Sciences·Anna BogdanovaLars Kaestner
Dec 20, 2017·Frontiers in Physiology·Pedro J Romero, Concepción Hernández-Chinea
Dec 26, 2001·Cell Death and Differentiation·E DaugasG Kroemer
Oct 12, 2014·The Journal of Biological Chemistry·Sviatoslav N BagriantsevPatrick G Gallagher
May 28, 2020·Frontiers in Physiology·Anna BogdanovaAsya Makhro
Jul 14, 2018·Analytical Cellular Pathology (Amsterdam)·Manoj Kumar Chaudhary, Syed Ibrahim Rizvi
Mar 14, 2021·Cellular and Molecular Life Sciences : CMLS·Merryn FraserAlexander G Maier

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