Differences in cerebral perfusion according to phenotypes of essential tremor: brain perfusion SPECT study using SPM analysis

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
In-Uk SongYong-An Chung

Abstract

Essential tremor (ET) is one of the most common movement disorders. However, few studies regarding the differences of pathophysiology according to phenotypes of ET have been reported. We investigated whether a functional difference occurs between ET with only a limb tremor (L-ET) and ET with only a head tremor (H-ET). We recruited 13 patients with L-ET, 10 patients with H-ET, and 33 healthy subjects. We compared the severity of tremor symptoms using the Fahn-Tolosa-Marin rating scale (FTM) to compare L-ET with H-ET. All subjects underwent magnetic resonance imaging and perfusion SPECT of the brain. The total score of FTM was significantly higher in the L-ET than in the H-ET. However, Part A in FTM did not show significant differences between the two ET groups. A brain perfusion SPECT analysis demonstrated no significant difference between L-ET and H-ET, but a regional perfusion of subjects with ET compared with healthy subjects showed hypoperfusion in the insular, cingulate gyrus, frontal lobe, and cerebellum. In conclusion, we suggested that cerebellar dysfunction might be involved in the pathogenesis of ET. In addition, we assumed that ET has the same pathogenesis in the origin of the disease, regardless of the clinical diffe...Continue Reading

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Sep 15, 2015·Parkinsonism & Related Disorders·Caterina PaulettiFrancesco Fattapposta
Jun 26, 2015·Current Opinion in Neurology·Felix Gövert, Günther Deuschl
Jun 21, 2014·Current Opinion in Neurology·Elan D Louis
Jul 6, 2021·Frontiers in Neurology·Florian Holtbernd, N Jon Shah

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