Differences in clinical trial patient attributes and outcomes according to enrollment setting.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Elizabeth B LamontBarbara J McNeil

Abstract

During the last 25 years, National Cancer Institute (NCI) cooperative trial groups have extended trial networks from academic centers to include certain community and Veterans Health Administration (VHA) centers. We compared trial patients' attributes and outcomes by these enrollment settings. Studying 2,708 patients on one of 10 cooperative group, randomized lung trials at 272 institutions, we compared patient attributes by enrollment setting (ie, academic, community, and VHA affiliates). We used adjusted Cox regression to evaluate for survival differences by setting. Main member institutions enrolled 44% of patients; community affiliates enrolled 44%; and VHAs enrolled 12%. Patient attributes (ie, case-mix) of age, ethnicity, sex, and performance status varied by enrollment setting. After analysis was adjusted for patient case-mix, no mortality differences by enrollment setting were noted. Although trial patients with primarily advanced-stage lung cancer from nonacademic centers were older and had worse performance statuses than those from academic centers, survival did not differ by enrollment setting after analysis accounted for patient heterogeneity. An answer for whether long-term outcomes for patients at community and VH...Continue Reading

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Citations

Mar 7, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mary Beth LandrumBarbara J McNeil
Apr 24, 2014·Breast Cancer Research and Treatment·Rachel A FreedmanNancy L Keating
Apr 16, 2010·Annals of Surgical Oncology·Waddah B Al-RefaieDavid A Rothenberger
Aug 10, 2012·Advances in Surgery·Waddah B Al-Refaie, Selwyn M Vickers
Mar 5, 2016·Acta Oncologica·Marieke van de WalJudith Prins
Nov 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ralph M Meyer
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Oct 29, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Eliza M ParkAnna C Muriel
Jun 4, 2020·Occupational Therapy in Health Care·Leila DehghanNoureddin Nakhostin Ansari

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