Differences in coronary plaque morphology between East Asian and Western White patients: an optical coherence tomography study

Coronary Artery Disease
Krzysztof BryniarskiIk-Kyung Jang

Abstract

Prevalence of coronary artery disease as well as cardiac mortality varies between Asian and White patients. However, the link between race and plaque characteristics in patients with coronary artery disease remains largely unexplored. Thus, we aimed to investigate the detailed culprit plaque characteristics between East Asian and White patients using optical coherence tomography. A total of 101 East Asians were matched to 101 White patients. Matching parameters included age, sex, clinical presentation, hyperlipidemia, diabetes mellitus, and lesion location. There were no differences in underlying pathology (rupture vs. erosion) of acute coronary syndrome (P=0.935). Lesion length was longer (18.0±6.0 vs. 14.6±5.4 mm; P<0.002), lipid length was greater (9.4±4.6 vs. 7.2±3.8 mm; P<0.023), lipid index was higher (1635±987 vs. 1104±730; P=0.002), and mean reference area was larger (8.1±3.0 vs. 6.5±2.4 mm; P<0.021) in White patients compared with East Asian patients. There are significant differences in plaque morphology between East Asian and White patients even after controlling for confounders. Our findings underscore key differences in atherosclerosis between East Asian and White populations, and may have to be taken into consider...Continue Reading

References

Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·R T Lee, P Libby
Jun 26, 2002·Circulation·Andrew FarbRenu Virmani
May 29, 2004·The American Journal of Cardiology·Laura MauriRichard E Kuntz
Sep 1, 2004·Journal of the American College of Cardiology·Briain D MacNeillGuillermo J Tearney
Apr 25, 2006·Journal of the American College of Cardiology·Renu VirmaniFrank D Kolodgie
May 16, 2006·Journal of the American College of Cardiology·Stephen J NichollsSteven E Nissen
May 14, 2011·Journal of the American College of Cardiology·David VancraeynestJean-Louis J Vanoverschelde
Jan 24, 2013·The American Journal of Cardiology·Reni P RusinovaAkiko Maehara
Mar 29, 2013·Circulation. Cardiovascular Imaging·Koji KatoIk-Kyung Jang
Sep 10, 2013·JACC. Cardiovascular Imaging·Takashi KuboShaosong Zhang
Nov 25, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ryan D MadderDavid Erlinge
Jan 27, 2015·JACC. Cardiovascular Interventions·Jose M de la Torre HernándezFernando Alfonso
Mar 31, 2015·Atherosclerosis·Stacey J WinhamVirginia M Miller
Jan 9, 2016·Circulation. Cardiovascular Imaging·Daniel S OngIk-Kyung Jang

❮ Previous
Next ❯

Citations

Feb 9, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Shigeru SaitoUNKNOWN Disrupt CAD IV Investigators

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01110538

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.