Differences in cortisol concentrations in South Asian and European men living in the United Kingdom

Clinical Endocrinology
Rebecca M ReynoldsB R Walker

Abstract

The metabolic syndrome is more prevalent in South Asians in Britain than in the general population. Furthering our understanding of the underlying mechanisms is important because of the increased risk of cardiovascular disease associated with the metabolic syndrome. As it has been proposed that increased activity of the hypothalamic pituitary adrenal axis might underlie the metabolic syndrome, we hypothesized that plasma cortisol levels would be higher in South Asians and that increased cortisol levels would be associated with cardiovascular risk factors comprising the metabolic syndrome. The aim of the study was to examine ethnic differences in cortisol levels and to compare the relationships between cortisol levels and cardiovascular risk factors in men from different ethnic groups. Cross-sectional population-based study, Newcastle upon Tyne, UK. (Newcastle Heart project). Participants One hundred men, 40-67 years old, of European and South Asian (Indian, Pakistani, Bangladeshi) ancestry, with and without cardiovascular risk factors of the metabolic syndrome. Measurement of plasma cortisol and corticosteroid binding globulin in stored sera. After adjustment for age and the presence of cardiovascular risk factors, mean cortiso...Continue Reading

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Feb 20, 2009·Journal of Immigrant and Minority Health·Nahid J Rianon, Rafia S Rasu
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