Differences in cytochalasin D-induced surface alterations between chronic lymphocytic leukaemic and normal lymphocytes

Experientia
L Skinnider

Abstract

Cytochalasin D (CD) causes an unusual surface alteration in normal lymphocytes consisting of the formation of focal irregular club-shaped cell processes. Lymphocytes from chronic lymphocytic leukaemic cases did not show this change on exposure to CD. There was either no surface change or, in some cases, clear double-membrane lined vesicles were formed and appeared to be discharged from the cell. This difference in response may be related to the changes in cell membranes known to occur in malignant transformation.

References

Jul 29, 1976·The New England Journal of Medicine·G L Nicolson, G Poste
Nov 18, 1976·Nature·K G Sundqvist, A Ehrnst
Mar 1, 1975·Experimental Cell Research·J TannenbaumA F Miranda
Nov 1, 1975·The American Journal of Anatomy·W Bondareff, R L Tuttle
May 1, 1974·The Journal of Cell Biology·A F MirandaS W Tanenbaum
Jan 1, 1974·CRC Critical Reviews in Biochemistry·T D Pollard, R R Weihing
Jan 15, 1971·Science·N K WessellsK Yamada
Nov 1, 1951·The American Journal of Anatomy·I COSTERO, C M POMERAT
Apr 1, 1961·The Journal of Biophysical and Biochemical Cytology·M Belkin, W G Hardy

Citations

Jul 1, 1979·Experimental Cell Research·G V HeniusJ D Woodburn

Related Concepts

Plasma Membrane
Cytochalasins
Lymphoid Leukemia
Lymphoid Cells
Surface Properties

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