Differences in driver genes between smoking-related and non-smoking-related lung cancer in the Chinese population

Cancer
Lan-Ying GouWen-Zhao Zhong

Abstract

Recently, non-smoking-related lung cancer was classified as an independent disease entity because it is different from tobacco-associated lung cancer. Non-smoking-related lung cancer occurs more often in women than men, and the predominant histological type is adenocarcinoma (ADC) rather than squamous cell carcinoma. Most of the driver gene alterations that have been identified in ADC in never-smokers include epidermal growth factor receptor mutations, KRAS mutations, echinoderm microtubule-associated protein like 4/anaplastic lymphoma kinase fusion, and ROS1 fusion, among others. Meanwhile, significant progress has been made in the treatment of ADC. However, in comparison with ADC, no such available molecular targets exist for smoking-associated lung cancer, for which treatment strategies are limited. Next-generation sequencing has been widely applied to the discovery of more genetic profiles of lung cancers. This review summarizes the differences between smoking-related and non-smoking-related lung cancer as follows: different somatic mutation burdens, C:G→A:T transversions, common and novel driver genes, and treatment strategies. Overall, smoking-related lung cancer is more complicated than non-smoking-related lung cancer. F...Continue Reading

References

Nov 15, 1994·International Journal of Cancer. Journal International Du Cancer·D M ParkinE Masuyer
Sep 30, 1950·British Medical Journal·R DOLL, A B HILL
May 3, 2005·Cytokine & Growth Factor Reviews·Richard Grose, Clive Dickson
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yoshio TomizawaMasatomo Mori
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chee-Keong TohEng-Huat Tan
Feb 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Heather A WakeleeDee W West
Sep 21, 2007·Nature Reviews. Cancer·Sophie SunAdi F Gazdar
Oct 25, 2008·Nature·Li DingRichard K Wilson
Jan 27, 2009·Cancer·Daisy Wing-Sze WongUNKNOWN University of Hong Kong Lung Cancer Study Group
Jun 18, 2009·Current Opinion in Oncology·Giorgio V ScagliottiSilvia Novello
Aug 12, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alice T ShawA John Iafrate
Aug 21, 2009·The New England Journal of Medicine·Tony S MokMasahiro Fukuoka
Dec 18, 2009·Nature·Erin D PleasancePeter J Campbell
Dec 19, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Guang JinJae Yong Park
Jan 23, 2010·Nature Reviews. Cancer·Nicholas Turner, Richard Grose
Jun 17, 2010·Nature Reviews. Clinical Oncology·Filip JankuRazelle Kurzrock
Sep 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yihua SunHongbin Ji
Jan 29, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Young Joo LeeByoung Chul Cho
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul K PaikGregory J Riely
Aug 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio MarchettiFiamma Buttitta
Jan 5, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kristin BergethonA John Iafrate
Jan 31, 2012·The Lancet Oncology·Rafael RosellUNKNOWN Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia T
Feb 14, 2012·Nature Medicine·Doron LipsonPhilip J Stephens
Feb 14, 2012·Nature Medicine·Kengo TakeuchiYuichi Ishikawa
Feb 14, 2012·Nature Medicine·Takashi KohnoTatsuhiro Shibata
Jan 1, 2011·Cancer Biomarkers : Section a of Disease Markers·Jianping XuLifen Ren-Heidenreich
May 2, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas J LynchMartin Reck

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Citations

Sep 4, 2015·Cancer·Suresh S Ramalingam, Fadlo R Khuri
Apr 19, 2018·International Journal of Cancer. Journal International Du Cancer·Wenxin LuoWeimin Li
Oct 27, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Francois Ng Kee KwongKian Fan Chung
Jul 11, 2020·Journal of Comparative Effectiveness Research·Paula ChuMonica Daigl
Aug 14, 2019·Expert Review of Proteomics·Toshihide NishimuraHisashi Saji
Sep 28, 2017·Journal of Medical Case Reports·Pan YangXia-Xiang Jin
Nov 4, 2020·Cancer Discovery·Dan ShaFrank A Sinicrope
Mar 18, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Laura MezquitaBenjamin Besse

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