Differences in E-Cadherin and Syndecan-1 Expression in Different Types of Ameloblastomas

Analytical Cellular Pathology (Amsterdam)
Ramón Gil Carreón-BurciagaRonell Bologna-Molina

Abstract

Ameloblastomas are a group of benign, locally aggressive, recurrent tumors characterized by their slow and infiltrative growth. E-Cadherin and syndecan-1 are cell adhesion molecules related to the behavior of various tumors, including ameloblastomas. Ninety-nine ameloblastoma samples were studied; the expression of E-cadherin and syndecan-1 were evaluated by immunohistochemistry. E-Cadherin and epithelial syndecan-1 were more highly expressed in intraluminal/luminal unicystic ameloblastoma than in mural unicystic ameloblastoma and solid/multicystic ameloblastoma, whereas the stromal expression of syndecan-1 was higher in mural unicystic ameloblastoma and solid/multicystic ameloblastoma. Synchronicity was observed between E-cadherin and epithelial syndecan-1; the expression was correlated with intensity in all cases. There was a strong association between expression and tumor size and recurrence. The evaluation of the expression of E-cadherin and syndecan-1 are important for determining the potential aggressiveness of ameloblastoma variants. Future studies are required to understand how the expression of these markers is related to tumor aggressiveness.

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Citations

Aug 1, 2020·International Journal of Dentistry·Huda M HammadRima A Safadi

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Methods Mentioned

BETA
SMA

Software Mentioned

Ecad
ImageJ
SMA
ImmunoMembrane

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