Differences in efficacy of two commercial 0.2% chlorhexidine mouthrinse solutions: a 4-day plaque re-growth study

Journal of Clinical Periodontology
Nicole Birgit ArweilerThorsten Mathias Auschill

Abstract

The purpose of this clinical cross-over study was to examine the antibacterial and plaque-inhibiting properties of two chlorhexidine solutions compared with a negative control. Twenty-one volunteers refrained from all oral hygiene measures, but rinsed instead twice daily with 10 ml of a conventional chlorhexidine solution (0.2%; CHX), a chlorhexidine solution with anti-discolouration system (ADS) (0.2%, alcohol-free chlorhexidine solution (CSP)) or a placebo solution (Pla). Plaque index (PI), plaque area (PA) and bacterial vitality were assessed after 24 h (PI1, vital flora (VF)1) and 96 h (PI2; VF2, PA). After a 10-day wash-out period, a new test cycle was started. Results for Pla were 0.94, 1.59, 27.4 (PI1, PI2, PA) and 79% and 72% (VF1 and VF2). CSP significantly reduced the parameter PI1, PI2 and PA to 0.67 (p=0.012), 1.0 and 15.7 (p<0.001). VF1 and VF2 (63% and 53%) were not significantly affected. The corresponding figures of CHX were 0.42, 0.43, 6.77, 33 and 16%, which were all significantly lower (all p<0.001). On comparing the two chlorhexidine solutions, CHX showed significantly higher reductions of all parameters. The results suggest that the 0.2% alcohol-containing solution showed superiority in inhibiting plaque re...Continue Reading

References

Sep 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J G Elmore, R I Horwitz
Jun 4, 1994·BMJ : British Medical Journal·J Llewelyn
Dec 12, 1997·European Journal of Oral Sciences·A GaffarN Nabi
Jun 27, 1998·Periodontology 2000·C G Jones
Nov 10, 2000·Journal of Clinical Periodontology·J MoranI Marlow
Apr 2, 2002·Journal of Periodontology·J L Leyes BorrajoTorreira M Gallas
Oct 2, 2002·Journal of Clinical Periodontology·Nicole B ArweilerLutz Netuschil
Mar 13, 2003·Journal of Clinical Periodontology·Nicole B ArweilerAnton Sculean
Feb 5, 2005·Journal of Clinical Periodontology·Thorsten M AuschillNicole B Arweiler
Mar 16, 2005·Journal of Clinical Periodontology·D A C Van StrydonckG A van der Weijden
Apr 7, 2005·Journal of Clinical Periodontology·Marc QuirynenDaniel van Steenberghe
Feb 3, 2006·International Journal of Dental Hygiene·M AddyJ Moran
Feb 3, 2006·International Journal of Dental Hygiene·F BernardiL Montebugnoli

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Citations

May 23, 2009·Clinical Oral Investigations·Isabelle SliepenWim Teughels
Mar 2, 2011·Clinical Oral Investigations·Nicole Birgit ArweilerAnton Sculean
Nov 28, 2009·British Dental Journal·C W de A Werner, R A Seymour
Jan 29, 2008·Applied and Environmental Microbiology·Shoji TakenakaPhilip S Stewart
Jan 5, 2014·PloS One·Lucía García-CaballeroInmaculada Tomás
May 19, 2012·International Journal of Dental Hygiene·N W D van Maanen-SchakelG A Van der Weijden
Jun 10, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Alev Aksoy DoganFatih Koksal
May 27, 2016·American Journal of Veterinary Research·Isabelle C JeusetteDavid Herrera
Aug 4, 2016·Frontiers in Microbiology·Isabel Prada-LópezInmaculada Tomás
Dec 3, 2017·Periodontology 2000·Nicole Birgit ArweilerAnton Sculean
Sep 7, 2019·Journal of Oral Microbiology·Nizam AbdullahLakshman Perera Samaranayake
May 16, 2012·International Journal of Dental Hygiene·A SinghJ Dixit
Dec 12, 2018·Clinical Oral Investigations·Alex SoldererPatrick R Schmidlin
May 18, 2017·Brazilian Oral Research·Gabriela Otero Dos SantosPatricia Weidlich
Oct 29, 2019·The Journal of Clinical Pediatric Dentistry·Eman Abu-ObaidSayed Auda

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