Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction

Clinical Epigenetics
Ana Monteagudo-SánchezDavid Monk

Abstract

Genome-wide studies have begun to link subtle variations in both allelic DNA methylation and parent-of-origin genetic effects with early development. Numerous reports have highlighted that the placenta plays a critical role in coordinating fetal growth, with many key functions regulated by genomic imprinting. With the recent description of wide-spread polymorphic placenta-specific imprinting, the molecular mechanisms leading to this curious polymorphic epigenetic phenomenon is unknown, as is their involvement in pregnancies complications. Profiling of 35 ubiquitous and 112 placenta-specific imprinted differentially methylated regions (DMRs) using high-density methylation arrays and pyrosequencing revealed isolated aberrant methylation at ubiquitous DMRs as well as abundant hypomethylation at placenta-specific DMRs. Analysis of the underlying chromatin state revealed that the polymorphic nature is not only evident at the level of allelic methylation, but DMRs can also adopt an unusual epigenetic signature where the underlying histones are biallelically enrichment of H3K4 methylation, a modification normally mutually exclusive with DNA methylation. Quantitative expression analysis in placenta identified two genes, GPR1-AS1 and ZD...Continue Reading

References

Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marika CharalambousAndrew Ward
Nov 3, 2004·Clinics in Perinatology·Ursula F Harkness, Giancarlo Mari
Feb 11, 2005·Acta Paediatrica. Supplement·D J P Barker
Jul 26, 2008·Seminars in Perinatology·Jena MillerAhmet A Baschat
Jun 2, 2009·Epigenetics : Official Journal of the DNA Methylation Society·Andreas I DiplasJia Chen
Jul 28, 2009·Annual Review of Genomics and Human Genetics·Marilyn B RenfreeAndrew J Pask
Jun 23, 2011·Reproductive Sciences·Luca LambertiniJia Chen
Jul 7, 2011·Disease Models & Mechanisms·Simon J TunsterRosalind M John
Nov 4, 2011·The American Journal of Clinical Nutrition·Anne GaboryClaudine Junien
Jun 15, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Hisato KobayashiTomohiro Kono
Sep 12, 2013·Environmental Health Perspectives·Payam DadvandMark J Nieuwenhuijsen
Mar 5, 2014·Genes & Development·Rachel DuffiéDéborah Bourc'his
Jul 6, 2014·Journal of Assisted Reproduction and Genetics·Amilcar CordeiroSofia Dória
Jan 21, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Gudrun E MoorePhilip Stanier
May 15, 2015·The International Journal of Biochemistry & Cell Biology·David Monk
Jul 18, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Maya A KappilJia Chen
Jan 16, 2016·Genome Research·Courtney W HannaWendy P Robinson
Nov 4, 2016·Nature Reviews. Endocrinology·Emma L WakelingIrène Netchine
Nov 3, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Jelena Milosevic-StevanovicIvana Djordjevic
Sep 30, 2016·Nature·Momoko HorikoshiRachel M Freathy
Nov 15, 2016·Nature Genetics·Maxim V C GreenbergDéborah Bourc'his
Nov 16, 2016·American Journal of Human Genetics·Hirotaka HamadaTakahiro Arima

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Citations

Oct 9, 2019·Medicine·Xia Chen, Ruhong Zhang
Oct 23, 2019·Molecular Biology and Evolution·Claudius VincenzBeverly I Strassmann
Apr 24, 2020·PLoS Genetics·Courtney W Hanna
Feb 19, 2020·Human Reproduction Update·Miriam ElbrachtThomas Eggermann
May 2, 2020·International Journal of Environmental Research and Public Health·Ali GhanchiBabak Khoshnood
Jun 3, 2021·Genes & Development·Courtney W Hanna, Gavin Kelsey
Jul 3, 2021·International Journal of Molecular Sciences·Sebastian CanovasPilar Coy

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Datasets Mentioned

BETA
AB8898

Methods Mentioned

BETA
biopsy
Assay
PCR
immunoprecipitations
immunoprecipitation
ChIP
PCRs
SGA
methylation profiling
biopsies

Software Mentioned

house
BeadStudio
Statistical Package for Social Sciences ( SPSS
R scripts
UCSC sequence browser
Pyro Q - CpG1

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