Differences in functional brain connectivity alterations associated with cerebral amyloid deposition in amnestic mild cognitive impairment

Frontiers in Aging Neuroscience
Dahyun YiDong Young Lee

Abstract

Despite potential implications for the early detection of impending Alzheimer's disease (AD), very little is known about the differences of large-scale brain networks between amnestic mild cognitive impairment (aMCI) with high cerebral amyloid-beta protein (Aβ) deposition (i.e., aMCI+) and aMCI with no or very little Aβ deposition (i.e., aMCI-). We first aimed to extend the current literature on altering intrinsic functional connectivity (FC) of the default mode network (DMN) and salience network (SN) from cognitively normal (CN) to AD dementia. Second, we further examined the differences of the DMN and the SN between aMCI-, aMCI+, and CN. Forty-three older adult (12 CN, 10 aMCI+, 10 aMCI-, and 11 AD dementia) subjects were included. All participants received comprehensive clinical and neuropsychological assessment, resting-state functional magnetic resonance imaging, structural MRI, and Pittsburgh compound-B-PET scans. FC data were preprocessed using multivariate exploratory linear optimized decomposition into independent components of FMRIB's Software Library. Group comparisons were carried out using the "dual-regression" approach. In addition, to verify presence of gray matter volume changes with intrinsic functional network...Continue Reading

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Citations

Jan 7, 2016·Frontiers in Aging Neuroscience·Manuel Menéndez-González, Tania Álvarez-Avellón
Jan 13, 2015·Neuropsychologia·Eleonora CatricalàStefano F Cappa
Mar 8, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·ChunLei WangWeiFeng Guo
Jun 26, 2020·Frontiers in Aging Neuroscience·Elizabeth E MooreAngela L Jefferson
Jun 1, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·AmanPreet BadhwarPierre Bellec
Feb 23, 2020·Frontiers in Human Neuroscience·Qi-Hui ZhouJiang-Hong Liu
Nov 13, 2020·Brain and Behavior·María Dolores Figueroa-JimenezJoan Guàrdia-Olmos
May 25, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Qiliang HeAnnabelle C Singer

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Software Mentioned

SPM2
VBM8
SPM8
FMRIB Software Library ( FSL
MELODIC
Statistical Package for the Social Sciences
mni2tal
MatLab
gICA
DARTEL

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