Differences in gene expression between B-cell chronic lymphocytic leukemia and normal B cells: a meta-analysis of three microarray studies

Bioinformatics
J WangLynne V Abruzzo

Abstract

A major focus of current cancer research is to identify genes that can be used as markers for prognosis and diagnosis, and as targets for therapy. Microarray technology has been applied extensively for this purpose, even though it has been reported that the agreement between microarray platforms is poor. A critical question is: how can we best combine the measurements of matched genes across microarray platforms to develop diagnostic and prognostic tools related to the underlying biology? We introduce a statistical approach within a Bayesian framework to combine the microarray data on matched genes from three investigations of gene expression profiling of B-cell chronic lymphocytic leukemia (CLL) and normal B cells (NBC) using three different microarray platforms, oligonucleotide arrays, cDNA arrays printed on glass slides and cDNA arrays printed on nylon membranes. Using this approach, we identified a number of genes that were consistently differentially expressed between CLL and NBC samples.

Citations

Jul 17, 2008·Comparative and Functional Genomics·John R Stevens, R W Doerge
Sep 20, 2007·Functional & Integrative Genomics·Erin M Conlon
Mar 4, 2006·Plant Molecular Biology·Byung-Hoon Kim, Albrecht G von Arnim
Nov 28, 2012·Biomolecular NMR Assignments·Leonhard GeistRobert Konrat
Jun 10, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David HuiRaymond Lai
Oct 31, 2006·Omics : a Journal of Integrative Biology·Ola LarssonRickard Sandberg
Mar 5, 2010·Bioinformatics·Amin Moghaddas Gholami, Kurt Fellenberg
Oct 15, 2009·Nucleic Acids Research·Wan-Jen HongGilbert Chu
May 8, 2007·Annual Review of Phytopathology·Roger P WiseSteven A Whitham
Jan 3, 2009·BMC Bioinformatics·Shuangge Ma, Jian Huang
Mar 9, 2007·BMC Bioinformatics·Erin M ConlonAnna Liu
Aug 9, 2008·BMC Bioinformatics·Andreas W SchreiberGeoffrey B Fincher
Jan 1, 2009·Journal of the American Statistical Association·Robert B ScharpfAndrew B Nobel
Sep 5, 2008·PLoS Medicine·Adaikalavan RamasamyDouglas G Altman
Jun 10, 2014·BMC Bioinformatics·Chun-Pei ChengVincent S Tseng
Jun 28, 2005·Computational Biology and Chemistry·Xiaohong HuangJennifer Hall
Jun 15, 2010·Cell Cycle·Jörg Hartkamp, Stefan G E Roberts
Feb 15, 2005·BMC Bioinformatics·Yingdong ZhaoRichard Simon

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