Abstract
This study was performed to identify differences in gene expression between superficial noninvasive and invasive transitional cell carcinoma (TCC) of the bladder in human beings. We used complementary deoxyribonucleic acid microarrays containing 14,551 different genes to analyze gene expression among 6 cases of superficial and 6 cases of invasive TCC of the bladder to identify differences in gene expression, which might explain differences in the biology and clinical outcomes of these histologic subtypes of TCC. Quantitative real-time polymerase chain reaction was performed for selected genes to validate the microarray data. Significant up-regulation of 40 genes was associated with cases of superficial noninvasive, but not in invasive, TCC of the urinary bladder. This effect included genes involved in epithelial cell dedifferentiation and keratinization, as well as genes related to cell cycle, cell adhesion, transcription, and apoptosis. Conversely, significant up-regulation of 34 genes was associated with cases of invasive TCC, but not in superficial TCC, including genes related to extracellular matrix degradation, immune responses, cell cycling, and angiogenesis. This study shows the usefulness of complementary deoxyribonucle...Continue Reading
References
Apr 1, 1996·Molecular and Cellular Biology·M L KireevaL F Lau
Oct 13, 2001·The Journal of Biological Chemistry·X TongH P Koeffler
Oct 31, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·S LiH Kanetake
May 11, 2002·Scandinavian Journal of Urology and Nephrology·K ZiegerK Højgaard
Jul 12, 2002·American Journal of Clinical Pathology·Alfredo BlanesSalvador J Diaz-Cano
Aug 21, 2002·Urologia Internationalis·Toshihiro SaitoKota Takahashi
Sep 28, 2002·Urology·Markus D SachsRonald Rodriguez
Nov 22, 2002·Oncogene·Miaw-Sheue TsaiRuth Lupu
Mar 20, 2003·Urologic Oncology·Sun Ying-HaoMao Yu-Ming
Apr 4, 2003·Cancer·Sana Al-Sukhun, Maha Hussain
Aug 6, 2003·Critical Reviews in Oncology/hematology·Sana Al-Sukhun, Maha Hussain
Oct 1, 2003·Pathology International·Hua-Chuan ZhengYan Xin
Oct 25, 2003·Oncogene·Orna MorAviv Regev
Feb 26, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sunanda J ChatterjeeRichard J Cote
May 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Olga ModlichMarc-Oliver Grimm
Nov 5, 2004·World Journal of Gastroenterology : WJG·Zhi-Jun ZengWei Wang
Citations
Oct 2, 2009·Future Oncology·Andrea B ApoloDean F Bajorin
Jan 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Markus RiesterFranziska Michor
Nov 22, 2013·PloS One·Guangping TaiAdrian S Woolf
Dec 1, 2009·Urologic Oncology·Matthew F WszolekIan C Summerhayes
Sep 27, 2008·Urologic Oncology·Hai Tao NiuJi Wu Chang
Sep 19, 2008·Urologic Oncology·Lori A NeelyIan C Summerhayes
Mar 27, 2007·Seminars in Oncology·Marta Sánchez-Carbayo, Carlos Cordon-Cardó
Dec 20, 2007·Current Opinion in Urology·Shahrokh F ShariatSeth P Lerner
Jun 1, 2013·Arab Journal of Urology·Mohamed GadelmoulaHiro-Omi Kanayama
Sep 28, 2017·Journal of Cancer Research and Clinical Oncology·Akihiro AsaiHideki Sakai
Mar 6, 2017·International Journal of Oncology·Syed A HussainNicholas D James
Aug 26, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin LaussMattias Höglund