Differences in genetic variation in antigen-processing machinery components and association with cervical carcinoma risk in two Indonesian populations

Immunogenetics
Akash M MehtaEkaterina S Jordanova

Abstract

Genetic variation of antigen-processing machinery (APM) components has been shown to be associated with cervical carcinoma risk and outcome in a genetically homogeneous Dutch population. However, the role of APM component single nucleotide polymorphisms (SNPs) in genetically heterogeneous populations with different distributions of human papillomavirus (HPV) subtypes remains unclear. Eleven non-synonymous, coding SNPs in the TAP1, TAP2, LMP2, LMP7 and ERAP1 genes were genotyped in cervical carcinoma patients and healthy controls from two distinct Indonesian populations (Balinese and Javanese). Individual genotype and allele distributions were investigated using single-marker analysis, and combined SNP effects were assessed by haplotype construction and haplotype interaction analysis. Allele distribution patterns in Bali and Java differed in relation to cervical carcinoma risk, with four ERAP1 SNPs and one TAP2 SNP in the Javanese population showing significant association with cervical carcinoma risk, while in the Balinese population, only one TAP2 SNP showed this association. Multimarker analysis demonstrated that in the Javanese patients, one specific haplotype, consisting of the ERAP1-575 locus on chromosome 5 and the TAP2-3...Continue Reading

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Citations

Dec 5, 2015·Frontiers in Oncology·Paul EggletonEdwin Bremer
Jul 7, 2015·Analytical Cellular Pathology (Amsterdam)·Akash M MehtaEkaterina S Jordanova
Sep 24, 2016·Immunology·Emma Reeves, Edward James
Jul 14, 2018·Omics : a Journal of Integrative Biology·Oppah KuguyoCollet Dandara
Mar 19, 2020·Cells·Irma SaulleMara Biasin
May 11, 2019·Journal of Cellular Biochemistry·Rongzeng LiuXiafei Chen
Mar 11, 2017·Journal of Immunology Research·Akash M MehtaEkaterina S Jordanova

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Methods Mentioned

BETA
Genotyping
PCR
Assay

Software Mentioned

Haploview
SPSS
FAMHAP
Sequence Detection Systems

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