Differences in GFR and Tissue Oxygenation, and Interactions between Stenotic and Contralateral Kidneys in Unilateral Atherosclerotic Renovascular Disease

Clinical Journal of the American Society of Nephrology : CJASN
Sandra M S HerrmannStephen C Textor

Abstract

Atherosclerotic renal artery stenosis (ARAS) can reduce renal blood flow, tissue oxygenation, and GFR. In this study, we sought to examine associations between renal hemodynamics and tissue oxygenation with single-kidney function, pressor hormones, and inflammatory biomarkers in patients with unilateral ARAS undergoing medical therapy alone or stent revascularization. Nonrandomized inpatient studies were performed in patients with unilateral ARAS (>60% occlusion) before and 3 months after revascularization (n=10) or medical therapy (n=20) or patients with essential hypertension (n=32) under identical conditions. The primary study outcome was change in single-kidney GFR. Individual kidney hemodynamics and volume were measured using multidetector computed tomography. Tissue oxygenation (using R(2)* as a measure of deoxyhemoglobin) was determined by blood oxygen level-dependent magnetic resonance imaging at 3 T. Renal vein neutrophil gelatinase-associated lipocalin (NGAL), monocyte chemoattractant protein-1 (MCP-1), and plasma renin activity were measured. Total GFR did not change over 3 months in either group, but the stenotic kidney (STK) GFR rose over time in the stent compared with the medical group (+2.2[-1.8 to 10.5] versus ...Continue Reading

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Citations

May 27, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Stephen C Textor, Sanjay Misra
Feb 28, 2016·Life Sciences·Sandeep Kaur, Arunachalam Muthuraman
Aug 24, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Menno PruijmPottumarthi Vara Prasad
May 4, 2017·Journal of the American Society of Nephrology : JASN·Ahmed SaadStephen C Textor
Feb 6, 2017·Current Hypertension Reports·Patricia Van der NiepenAlexandre Persu
Jun 3, 2021·Antioxidants·Áine M de BhailísPhilip A Kalra

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