Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer. A five year follow up

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Johanna NyqvistBjörn Zackrisson

Abstract

Health related quality of life (HRQoL) was assessed in the randomised, prospective ARTSCAN study comparing conventional radiotherapy (CF) with accelerated radiotherapy (AF) for head and neck cancer. 750 patients with squamous cell carcinoma (of any grade and stage) in the oral cavity, oro-, or hypopharynx or larynx (except T1-2, N0 glottic carcinoma) without distant metastases were randomised to either conventional fractionation (2 Gy/day, 5 days/week in 49 days, total dose 68 Gy) or accelerated fractionation (1.1+2.0 Gy/day, 5 days/week in 35 days, total dose 68 Gy). HRQoL was assessed with EORTC QLQ-C30, QLQ-H&N35 and HADS at baseline, at end of radiotherapy (eRT) and at 3 and 6 months and 1, 2 and 5 years after start of treatment. The AF group reported HRQoL was significantly lower at eRT and at 3 months for most symptoms, scales and functions. Few significant differences were noted between the groups at 6 months and 5 years. Scores related to functional oral intake never reached baseline. In comparison to CF, AF has a stronger adverse effect on HRQoL in the acute phase.

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Citations

Oct 1, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Karin SöderströmEva Levring Jäghagen
Mar 1, 2017·International Journal of Radiation Oncology, Biology, Physics·Jolie Ringash
May 7, 2020·Clinical and Translational Radiation Oncology·Sonja StiebUNKNOWN MD Anderson Head and Neck Cancer Symptom Working Group

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