Differences in HIV type 1 RNA plasma load profile of closely related cocirculating Ethiopian subtype C strains: C and C'

AIDS Research and Human Retroviruses
Workenesh AyeleGeorgios Pollakis

Abstract

Two HIV-1 subtype C subclusters have been identified in Ethiopia (C and C') with little knowledge regarding their biological or clinical differences. We longitudinally monitored HIV-1 viral loads and CD4(+) T cell counts for 130 subtype C-infected individuals from Ethiopia over 5 years. The genetic subclusters C and C' were determined and comparisons were made between the groups. None of the study individuals received antiretroviral therapy. Subcluster C' was found to be the more prevalent (72.3%) genotype circulating. Individuals infected with subcluster C' harbored higher viral loads in comparison to subcluster C-infected individuals when the CD4(+) T cell counts were high (500-900 cells/mm(3)), whereas at low CD4(+) T cell counts (0-150 cells/mm(3)) individuals infected with subcluster C viruses showed higher viral loads. We identified a greater number of deaths among individuals infected with subcluster C viruses in comparison to C'. Our results indicate that infection with subcluster C viruses leads to a more rapid onset of disease, despite the initial lower HIV-1 RNA plasma loads. Additionally, the higher viral loads seen for HIV-1 subcluster C' infections at higher CD4(+) T cell counts can help explain the higher prevale...Continue Reading

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Citations

Dec 27, 2005·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·U Marcus
Aug 19, 2011·The New England Journal of Medicine·Mark A WainbergBluma G Brenner
Aug 1, 2012·PloS One·Edson Oliveira Delatorre, Gonzalo Bello
Mar 21, 2012·Theoretical Biology & Medical Modelling·Diego F Cuadros, Gisela García-Ramos
Mar 2, 2011·Journal of Medical Virology·Bluma G BrennerMichel Roger

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

STAT
PHYLIP
Prism
DNADIST
SAS

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