Differences in homeostatic model assessment (HOMA) values and insulin levels after vitamin D supplementation in healthy men: a double-blind randomized controlled trial

Diabetes, Obesity & Metabolism
Sigal TepperS Ish-Shalom

Abstract

Vitamin D is thought to play a role in glucose metabolism. The aim of the present study was to determine the effect of vitamin D supplementation on markers of insulin sensitivity and inflammation in men without diabetes with vitamin D deficiency/insufficiency. In this 1-year double-blind randomized controlled trial, 130 men aged 20-65 years (mean age 47.52 ± 11.84 years) with serum 25-hydroxyvitamin D levels <50 nmol/l (mean 38.89 ± 8.64 nmol/l) were randomized to treatment (100 000 IU vitamin D bimonthly) or placebo. Anthropometric measurements, demographic questionnaires, and blood indices (fasting glucose, insulin, high-sensitivity C-reactive protein, lipids) were collected and repeated after 6 and 12 months. The compliance rate was 98.5%. Multivariate models, adjusted for baseline levels, age, body mass index, sun exposure, physical activity and LDL, showed significant differences in insulin and homeostatic model assessment of insulin resistance (HOMA-IR) values between groups. Levels of insulin and HOMA-IR values remained steady during the study period in the treatment group but increased by 16% in the control group (p = 0.038 and p = 0.048, respectively). Vitamin D supplementation administered for 12 months in healthy men...Continue Reading

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Citations

Jul 19, 2016·Archives of Toxicology·Giovanna MuscogiuriAnnamaria Colao
Sep 25, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Sunil J Wimalawansa
Sep 25, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Sunil J Wimalawansa
Oct 11, 2014·Diabetes & Metabolic Syndrome·Elena RyderNelson Fernández
May 10, 2017·Endocrinology·Edith Angellotti, Anastassios G Pittas
Mar 12, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Kaustubh Bora, Alice Abraham Ruram
Apr 10, 2019·Nutrients·Izabela Szymczak-Pajor, Agnieszka Śliwińska
Apr 15, 2017·Reviews in Endocrine & Metabolic Disorders·Stefania Giuliana Garbossa, Franco Folli
Jul 25, 2019·Current Pharmaceutical Design·Ana Valer-MartinezMaira Bes-Rastrollo
May 8, 2021·Journal of the American Heart Association·Jennifer MiaoThomas J Wang
Dec 29, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Sunil J Wimalawansa

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